Originally posted 18 Dec 19
The vast majority of diseases, including many cancers, diabetes, and Alzheimer’s, have a genetic contribution of just five to 10 per cent, shows the meta-analysis of data from studies that examine relationships between common gene mutations, or single nucleotide polymorphisms (SNPs), and different conditions.
“Simply put, DNA is not your destiny, and SNPs are duds for disease prediction,” said study co-author David Wishart, professor in the department of biological sciences and the department of computing science.
But there are exceptions, including Crohn’s disease, celiac disease, and macular degeneration, which have a genetic contribution of approximately 40 to 50 per cent.
“Despite these rare exceptions, it is becoming increasingly clear that the risks for getting most diseases arise from your metabolism, your environment, your lifestyle, or your exposure to various kinds of nutrients, chemicals, bacteria, or viruses,” said Wishart.
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