Greengrass C. J. (2026).
Frontiers in digital health, 7, 1715440.
Abstract
Clinical reasoning is foundational to medical practice, requiring clinicians to synthesise complex information, recognise patterns, and apply causal reasoning to reach accurate diagnoses and guide patient management. However, human cognition is inherently limited by factors such as limitations in working memory capacity, constraints in cognitive load, a general reliance on heuristics; with an inherent vulnerability to biases including anchoring, availability bias, and premature closure. Cognitive fatigue and cognitive overload, particularly apparent in high-pressure environments, further compromise diagnostic accuracy and efficiency. Artificial intelligence (AI) presents a transformative opportunity to overcome these limitations by supplementing and supporting decision-making. With AI's advanced computational capabilities, these systems can analyse large datasets, detect subtle or atypical patterns, and provide accurate evidence-based diagnoses. Furthermore, by leveraging machine learning and probabilistic modelling, AI reduces dependence on incomplete heuristics and potentially mitigates cognitive biases. It also ensures consistent performance, unaffected by fatigue or information overload. These attributes likely make AI an invaluable tool for enhancing the accuracy and efficiency of diagnostic reasoning. Through a narrative review, this article examines the cognitive limitations inherent in diagnostic reasoning and considers how AI can be positioned as a collaborative partner in addressing them. Drawing on the concept of Mutual Theory of Mind, the author identifies a set of indicators that should inform the design of future frameworks for human–AI interaction in clinical decision-making. These highlight how AI could dynamically adapt to human reasoning states, reduce bias, and promote more transparent and adaptive diagnostic support in high-stakes clinical environments.
Here are some thoughts:
This article examines how artificial intelligence can support clinical diagnostic reasoning by compensating for inherent human cognitive limitations such as limited working memory capacity, cognitive load, reliance on heuristics, and susceptibility to biases like anchoring and premature closure. The author integrates cognitive psychology concepts including dual process theory (System 1 intuitive pattern recognition versus System 2 analytical reasoning), cognitive load theory, and Bayesian reasoning to analyze how AI systems can reduce cognitive burden, provide external schema repositories, offer transparent explainable outputs, and support metacognitive monitoring. While AI offers advantages in processing vast data streams, maintaining multiple hypotheses, and performing consistently without fatigue, the review acknowledges current limitations of large language models including poor probabilistic reasoning and potential for algorithmic or transferred bias. The article concludes that AI should function as a collaborative partner within a Mutual Theory of Mind framework, enhancing rather than replacing human judgment, provided that ethical standards and clinician training keep pace with technological development.








