Is this “one of the worst scientific scandals of all time”?

Hans Eysenck

Stephen Fleischfresser
cosmosmagazine.com
Originally posted 21 October 2019

Here is an excerpt:

Another study on the efficacy of psychotherapy in preventing cancer showed 100% of treated subjects did not die of cancer in the following 13 years, compared to 32% of an untreated control group.

Perhaps most alarming results were connected to Eysenck and Grossath-Maticek’s notion of ‘bibliotherapy’ which consisted of, as Eysenck put it, “a written pamphlet outlining the principles of behaviour therapy as applied to better, more autonomous living, and avoidance of stress.”

This was coupled with five hours of discussion, aimed both at reorienting a patient’s personality away from the cancer-prone and toward a healthier disposition. The results of this study, according to Pelosi, were that “128 of the 600 (21%) controls died of cancer over 13 years compared with 27 of 600 (4.5%) treated subjects.

"Such results are otherwise unheard of in the entire history of medical science.” There were similarly spectacular results concerning various forms of heart disease too.

These decidedly improbable findings led to a blizzard of critical scrutiny through the 90s: Eysenck and Grossath-Maticek’s work was attacked for its methodology, statistical treatment and ethics.

One researcher who attempted a sympathetic review of the work, in cooperation with the pair, found, says Pelosi, “unequivocal evidence of manipulation of data sheets,” from the Heidelberg cohort, as well as numerous patient questionnaires with identical responses.

An attempt at replicating some of their results concerning heart disease provided cold comfort, indicating that the personality type association with coronary illness was non-existent for all but one of the types.

A slightly modified replication of Eysenck and Grossath-Maticek’s research on personality and cancer faired no better, with the author, Manfred Amelang, writing “I know of no other area of research in which the change from an interview to a carefully constructed questionnaire measuring the same construct leads to a change from near-perfect prediction to near-zero prediction.”

The info is here.

Artificial Intelligence as a Socratic Assistant for Moral Enhancement

Lara, F. & Deckers, J.
Neuroethics (2019).
https://doi.org/10.1007/s12152-019-09401-y

Abstract

The moral enhancement of human beings is a constant theme in the history of humanity. Today, faced with the threats of a new, globalised world, concern over this matter is more pressing. For this reason, the use of biotechnology to make human beings more moral has been considered. However, this approach is dangerous and very controversial. The purpose of this article is to argue that the use of another new technology, AI, would be preferable to achieve this goal. Whilst several proposals have been made on how to use AI for moral enhancement, we present an alternative that we argue to be superior to other proposals that have been developed.

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Here is a portion of the Conclusion

Given our incomplete current knowledge of the biological determinants of moral behaviour and of the use of biotechnology to safely influence such determinants, it is reckless to defend moral bioenhancement, even if it were voluntary. However, the age-old human desire to be morally better must be taken very seriously in a globalised world where local decisions can have far-reaching consequences and where moral corruption threatens the survival of us all. This situation forces us to seek the satisfaction of that desire by means of other technologies. AI could, in principle, be a good option. Since it does not intervene directly in our biology, it can, in principle, be less dangerous and controversial.

However, we argued that it also carries risks. For the exhaustive project, these include the capitulation of human decision-making to machines that we may not understand and the negation of what makes us ethical human beings. We argued also that even some auxiliary projects that do not promote the surrendering of human decision-making, for example systems that foster decision-making on the basis of moral agents’ own values, may jeopardise the development of our moral capacities if they focus too much on outcomes, thus providing insufficient opportunities for individuals to be critical of their values and of the processes by which outcomes are produced, which are essential factors for personal moral progress and for rapprochement between different individuals’ positions.

What School Shooters Have in Common

Jillian Peterson & James Densley
edweek.org
Originally posted October 8, 2019

Here is an excerpt:

However, school shooters are almost always a student at the school, and they typically have four things in common:

They suffered early-childhood trauma and exposure to violence at a young age. They were angry or despondent over a recent event, resulting in feelings of suicidality. They studied other school shootings, notably Columbine, often online, and found inspiration. And they possessed the means to carry out an attack.

By understanding the traits that school shooters share, schools can do more than just upgrade security or have students rehearse for their near-deaths. They can instead plan to prevent the violence.

To mitigate childhood trauma, for example, school-based mental-health services such as counselors and social workers are needed. Schools can also adopt curriculum focused on teaching positive coping skills, resilience, and social-emotional learning, especially to young boys (According to our data, 98 percent of mass shooters are men.)

A crisis is a moment, an inflection point, when things will either become very bad or begin to get better. In 80 percent of cases, school shooters communicated to others that they were in crisis, whether through a marked change in behavior, an expression of suicidal thoughts or plans, or specific threats of violence. For this reason, all adults in schools, from the principal to the custodian, need high-quality training in crisis intervention and suicide prevention and the time and space to connect with a student. At the same time, schools need formal systems in place for students and staff to (anonymously) report a student in crisis.

The info is here.

Memphis psychiatrist who used riding crop on patients now faces new charges

Brett Kelman

Nashville Tennessean
Originally published October 27, 2019

Here are two excerpts:

A Memphis-area psychiatrist whose license was suspended last year for using a riding crop on patients could now lose her license again due to an ongoing dispute with state health licensing officials.

Dr. Valerie Augustus, who runs Christian Psychiatric Services in the suburb of Germantown, was forced to close her clinic last June after a medical discipline trial proved to the Tennessee Board of Medical Examiners that she had used a riding crop or a whip on at least 10 patients. The clinic was permitted to re-open six months later after Augustus agreed to professional probation, but she continued to fight the case in court.

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Augustus, 57, ran her clinic for 17 years without any discipline issues before her license was suspended last year. A board order states that, in addition to using the whip and riding crop on patients, Augustus kept the items “displayed in her office” and “compared her patients to mules.”

The government’s attorney, Paetria Morgan, argued at the medical discipline trial that Augustus hit her patients if they did not lose weight or exercise. In addition to the whip and riding crop, Morgan alleged Augustus hit patients with a “four-foot stick of bamboo.”

“Her defense is that she hit them in jest,” Morgan said. “When did hitting become funny? Hitting isn’t hilarious. Hitting isn’t helpful. Hitting isn’t healing.”

The info is here.

A Sober Second Thought? A Pre-Registered Experiment on the Effects of Mindfulness Meditation on Political Tolerance

Michael Bang Petersen & Panagiotis Mitkidis
PsyArXiv
Originally posted October 20, 2019

Abstract

Mindfulness meditation is increasingly promoted as a tool to foster more inclusive and tolerant societies and, accordingly, meditation practice has been adopted in a number of public institutions including schools and legislatures. Here, we provide the first empirical test of the effects of mindfulness meditation on political and societal attitudes by examining whether completion in a 15-minute mindfulness meditation increases tolerance towards disliked groups relative to relevant control conditions. Analyses of data from a pilot experiment (N = 54) and a pre-registered experiment (N = 171) provides no evidence that mindfulness meditation increases political tolerance. Furthermore, exploratory analyses show that individual differences in trait mindfulness is not associated with differences in tolerance. These results suggest that there is reason to pause recommending mindfulness meditation as a way to achieve democratically desirable outcomes or, at least, that short-term meditation is not sufficient to generate these.

The research is here.

The ‘cancer growing in cancer medicine’: pharma money paid to doctors

Vinay Prasad
statnews.com
Originally posted October 30, 2019

Here is an excerpt:

The fundamental problem is that, as a profession, cancer physicians are not interested in addressing conflict of interest. Too many people in prominent positions benefit from the current lax policies. Disclosure is not the solution —ending these payments is.

I want to be clear: I’m all for doctors interacting with and working with the pharmaceutical and device industries. I have lectured at major pharmaceutical companies, but without accepting money, travel expenses, or meals. Researchers should be free to work with pharmaceutical companies on trials, but there is no legitimate reason why a well-paid physician needs to take personal payments, gifts, meals, or travel expenses from the pharmaceutical industry. That practice must end.

Conflict of interest is the cancer growing in cancer medicine. It poisons the field. It leads us to celebrate marginal drugs as if they were game-changers. It leads experts to ignore or downplay flaws and deficits in cancer clinical trials. It keeps doctors silent about the crushing price of cancer medicines. It is rampant in guidelines that lead to off-label prescribing and that mandate payment. It is surely a calculated maneuver by the industry to increase their profits.

The info is here.

Super-precise new CRISPR tool could tackle a plethora of genetic diseases

Heidi Ledford
nature.com
Originally posted October 21, 2019

For all the ease with which the wildly popular CRISPR–Cas9 gene-editing tool alters genomes, it’s still somewhat clunky and prone to errors and unintended effects. Now, a recently developed alternative offers greater control over genome edits — an advance that could be particularly important for developing gene therapies.

The alternative method, called prime editing, improves the chances that researchers will end up with only the edits they want, instead of a mix of changes that they can’t predict. The tool, described in a study published on 21 October in Nature1, also reduces the ‘off-target’ effects that are a key challenge for some applications of the standard CRISPR–Cas9 system. That could make prime-editing-based gene therapies safer for use in people.

The tool also seems capable of making a wider variety of edits, which might one day allow it to be used to treat the many genetic diseases that have so far stymied gene-editors. David Liu, a chemical biologist at the Broad Institute of MIT and Harvard in Cambridge, Massachusetts and lead study author, estimates that prime editing might help researchers tackle nearly 90% of the more than 75,000 disease-associated DNA variants listed in ClinVar, a public database developed by the US National Institutes of Health.

The specificity of the changes that this latest tool is capable of could also make it easier for researchers to develop models of disease in the laboratory, or to study the function of specific genes, says Liu.

The info is here.

Medical board declines to act against fertility doctor who inseminated woman with his own sperm

Dr. McMorries

Marie Saavedra and Mark Smith
wfaa.com
Originally posted Oct 28, 2019

The Texas Medical Board has declined to act against a fertility doctor who inseminated a woman with his own sperm rather than from a donor the mother selected.

Though Texas lawmakers have now made such an act illegal, the Texas Medical Board found the actions did not “fall below the acceptable standard of care,” and declined further review, according to a response to a complaint obtained by WFAA.

In a follow-up email, a spokesperson told WFAA the board was hamstrung because it can't review complaints for instances that happened seven years or more past the medical treatment. 

The complaint was filed on behalf of 32-year-old Eve Wiley, of Dallas, who only recently learned her biological father wasn't the sperm donor selected by her mother. Instead, Wiley discovered her biological father was her mother’s fertility doctor in Nacogdoches.

Now 65, Wiley's mother, Margo Williams, had sought help from Dr. Kim McMorries because her husband was infertile.

The info is here.

Moral Responsibility

Talbert, Matthew
The Stanford Encyclopedia of Philosophy 
(Winter 2019 Edition), Edward N. Zalta (ed.)

Making judgments about whether a person is morally responsible for her behavior, and holding others and ourselves responsible for actions and the consequences of actions, is a fundamental and familiar part of our moral practices and our interpersonal relationships.

The judgment that a person is morally responsible for her behavior involves—at least to a first approximation—attributing certain powers and capacities to that person, and viewing her behavior as arising (in the right way) from the fact that the person has, and has exercised, these powers and capacities. Whatever the correct account of the powers and capacities at issue (and canvassing different accounts is the task of this entry), their possession qualifies an agent as morally responsible in a general sense: that is, as one who may be morally responsible for particular exercises of agency. Normal adult human beings may possess the powers and capacities in question, and non-human animals, very young children, and those suffering from severe developmental disabilities or dementia (to give a few examples) are generally taken to lack them.

To hold someone responsible involves—again, to a first approximation—responding to that person in ways that are made appropriate by the judgment that she is morally responsible. These responses often constitute instances of moral praise or moral blame (though there may be reason to allow for morally responsible behavior that is neither praiseworthy nor blameworthy: see McKenna 2012: 16–17 and M. Zimmerman 1988: 61–62). Blame is a response that may follow on the judgment that a person is morally responsible for behavior that is wrong or bad, and praise is a response that may follow on the judgment that a person is morally responsible for behavior that is right or good.

The information is here.