Welcome to the Nexus of Ethics, Psychology, Morality, Philosophy and Health Care

Welcome to the nexus of ethics, psychology, morality, technology, health care, and philosophy
Showing posts with label Research Bias. Show all posts
Showing posts with label Research Bias. Show all posts

Monday, November 17, 2014

Is Social Psychology Biased Against Republicans?

By Maria Konnikova
The New Yorker
Originally published October 30, 2014

Here is an excerpt:

Social psychology, Haidt went on, had an obvious problem: a lack of political diversity that was every bit as dangerous as a lack of, say, racial or religious or gender diversity. It discouraged conservative students from joining the field, and it discouraged conservative members from pursuing certain lines of argument. It also introduced bias into research questions, methodology, and, ultimately, publications. The topics that social psychologists chose to study and how they chose to study them, he argued, suffered from homogeneity. The effect was limited, Haidt was quick to point out, to areas that concerned political ideology and politicized notions, like race, gender, stereotyping, and power and inequality. “It’s not like the whole field is undercut, but when it comes to research on controversial topics, the effect is most pronounced,” he later told me. (Haidt has now put his remarks in more formal terms, complete with data, in a paper forthcoming this winter in Behavioral and Brain Sciences.)

The entire article is here.

Tuesday, November 11, 2014

Researchers retract bogus, Dr. Oz-touted study on green coffee bean weight-loss pills

By Abby Phillip
The Washington Post
Originally published October 22, 2014

Researchers have retracted a bogus study that was used by a company to validate weight-loss claims for green coffee bean pills, one of several questionable supplements being scrutinized by federal regulators.

The study, which was conducted in India but written by researchers from the University of Scranton in Pennsylvania, initially claimed that people who used the supplement lost 16 percent of their body fat (about about 18 pounds each) with or without diet and exercise.

The entire story is here.

Sunday, June 16, 2013

Why do identical twins end up having such different lives?

Their genes are exactly the same, so why don't identical siblings' lives follow more similar patterns? The scientist behind a pioneering 21-year study believes he has the answer

By Robin McKie
The Guardian/The Observer
Originally published June 1, 2013

Here is one excerpt:

"We now began to look not at the similarities between identical twins but the differences. It was a shift in perception really. Our work shows that the heritability of your age at death is only about 25%. Similarly, there is only a 30% chance that if one identical twin gets heart disease the other one will as well, while the figure for rheumatoid arthritis is only about 15%."

It is a baffling observation: individuals with identical genes and often very similar conditions of upbringing but who experience very different life outcomes. What could be the cause? The answer, says Spector, came to him in a Damascene moment four years ago. The causes of these differences were due to changes in the human epigenome, he realised.

"Essentially, epigenetics is the mechanism by which environmental changes alter the behaviour of our genes," he says. "This involves a process known as methylation, which occurs when a chemical known as methyl, which floats around the inside of our cells, attaches itself to our DNA. When it does so, it can inhibit or turn down the activity of a gene and block it from making a particular version of a protein in our bodies." Crucially, all sorts of life events can affect DNA methylation levels in our bodies: diet, illnesses, ageing, chemicals in the environment, smoking, drugs and medicines.

Thus epigenetic changes produce variation in disease patterns. And recent experiments carried out by Spector and his colleagues, in which they have looked at methylation levels in pairs of identical twins, back the theory. "We have studied identical twins who have different tolerances to pain and shown that they have different states of methylation. We have also produced similar results for depression, diabetes and breast cancer. In each case, we have found genes that are switched on in one twin and switched off in the other twin. This often determines whether or not they are likely to get a disease."

Epigenetic changes are not just simple environmental changes, however. They influence a person's genes and can have an effect that can last for two or three generations in extreme cases. For example, studies of the children and grandchildren of pregnant women who endured starvation in the second world war and in China in the 50s have revealed they tended to be smaller and more prone to diabetes and psychosis. These trends are put down to epigenetic changes.

The entire article is here.

Thanks to Ed Zuckerman for this article.  The article may change the way that a psychologist thinks about twin study research indicating biological bases of psychopathology.

Friday, April 19, 2013

Scientific Articles Accepted (Personal Checks, Too)

By GINA KOLATA
The New York Times
Published: April 7, 2013

The scientists who were recruited to appear at a conference called Entomology-2013 thought they had been selected to make a presentation to the leading professional association of scientists who study insects.

But they found out the hard way that they were wrong. The prestigious, academically sanctioned conference they had in mind has a slightly different name: Entomology 2013 (without the hyphen). The one they had signed up for featured speakers who were recruited by e-mail, not vetted by leading academics. Those who agreed to appear were later charged a hefty fee for the privilege, and pretty much anyone who paid got a spot on the podium that could be used to pad a résumé.

“I think we were duped,” one of the scientists wrote in an e-mail to the Entomological Society.

Those scientists had stumbled into a parallel world of pseudo-academia, complete with prestigiously titled conferences and journals that sponsor them. Many of the journals and meetings have names that are nearly identical to those of established, well-known publications and events.

Steven Goodman, a dean and professor of medicine at Stanford and the editor of the journal Clinical Trials, which has its own imitators, called this phenomenon “the dark side of open access,” the movement to make scholarly publications freely available.

The entire story is here.

Thursday, October 25, 2012

7 More Cancer Scientists Quit Texas Institute Over Grants

By The Associated Press
Originally published on October 13, 2012

At least seven more scientists have resigned in protest from Texas’ embattled $3 billion cancer-fighting program, claiming that the agency in charge of it is charting a “politically driven” path that puts commercial interests before science.

The Cancer Prevention and Research Institute of Texas, created with the backing of Gov. Rick Perry and the cyclist Lance Armstrong, a cancer survivor, has awarded nearly $700 million in grants since 2009; only the National Institutes of Health offers a bigger pot of cancer-research money.

Sunday, June 3, 2012

Bias found in mental health drug research presented at major psychiatric meeting


When thousands of psychiatrists attend their field's largest annual meeting each year, the presentations they hear about research into drug treatments report overwhelmingly on positive results.

That's the finding of a new study published in the Journal of Clinical Psychopharmacology by two young psychiatrists from the University of Michigan and Yale University, who analyzed the presentations given at two recent meetings of the American Psychiatric Association.

Of 278 studies presented at the 2009 and 2010 APA meetings that compared at least two medicines against each other for any psychiatric illness, they found that 195 had been supported by industry, and 83 funded by other means. The authors then evaluated the studies without knowing which kind of support each one had.

Of the industry-supported studies, 97.4 percent reported results that were positive toward the medicine that the study was designed to test, and 2.6 percent reported mixed results. No industry-sponsored studies with negative results were found.

The entire article is here.

The journal article can be purchased here.