Ryan F. Mandelbaum
Originally published January 19, 2019
Chinese researchers have cloned five gene-edited monkeys with a host of genetic disease symptoms, according to two scientific papers published today.
The researchers say they want to use the gene-edited macaques for biomedical research; basically, they hope that engineering sick primates will reduce the total number of macaques used in research around the world. But their experiment is a minefield of ethical quandaries—and makes you wonder whether the potential benefits to science are enough to warrant all of the harm to these monkeys.
The researchers began by using CRISPR/Cas9 to alter the DNA of a donor macaque. CRISPR/Cas9 is the often-discussed gene editing tool derived from bacteria that combines repeating sequences of DNA and a DNA-cutting enzyme in order to customize DNA sequences. Experts and the press have heralded it as an important advance due to how quickly and cheaply it can alter DNA, but recent research has demonstrated it may cause more unintended effects than previously thought.
This research combines a ton of ethical issues into one package, from those surrounding animal rights to cloning to gene editing. As bioethicist Carolyn Neuhaus from The Hastings Center summarized her reaction to the announcement: “Whoa, this is a doozy.”
The info is here.