Welcome to the Nexus of Ethics, Psychology, Morality, Philosophy and Health Care

Welcome to the nexus of ethics, psychology, morality, technology, health care, and philosophy
Showing posts with label Biotechnology. Show all posts
Showing posts with label Biotechnology. Show all posts

Thursday, October 13, 2022

This company is about to grow new organs in a person for the first time

Jessica Hamzelou
MIT Technology Review
Originally posted 25 AUG 22

Here is an excerpt:

Livers have a unique ability to regenerate. Cut away half an animal’s liver, and it will grow back. Human livers damaged by toxins or alcohol can usually regrow too. But some diseases can cause extensive damage from which the liver can’t recover. For these diseases, the treatment of choice is usually a liver transplant.

Transplants aren’t always an option for people who are very unwell, however. That’s why Eric Lagasse and his colleagues at LyGenesis have taken this different approach. Lagasse, a stem-cell biologist at the University of Pittsburgh, has spent years researching cell-based treatments for liver disease. Around 10 years ago, he was experimenting with the idea of injecting cells from healthy livers into diseased ones in mice.

It is difficult to access the livers of small, 25-gram mice, which Lagasse was studying, so instead he and his colleagues injected the cells into the spleens of mice with liver disease. They found that the cells were able to migrate from the spleen to the liver. To find out if they could migrate from other organs, Lagasse’s team injected liver cells at various sites in the mice’s bodies.

Only a small number of mice survived. When Lagasse and his colleagues later performed autopsies on those survivors, “I was very surprised,” he recalls. “We had a mini liver present … where the lymph node would be.”

Little incubators

Lymph nodes are small, bean-shaped structures found throughout the body. They play a crucial role in our immune health, making cells that help fight infections. And while Lagasse was initially surprised that liver cells could multiply and grow in lymph nodes, it makes sense, he says. 

Lymph nodes are natural homes for rapidly dividing cells, even if those are usually immune cells. Lymph nodes also have a good blood supply, which can aid the growth of new tissue.


Wednesday, October 21, 2020

Neurotechnology can already read minds: so how do we protect our thoughts?

Rafael Yuste
El Pais
Originally posted 11 Sept 20

Here is an excerpt:

On account of these and other developments, a group of 25 scientific experts – clinical engineers, psychologists, lawyers, philosophers and representatives of different brain projects from all over the world – met in 2017 at Columbia University, New York, and proposed ethical rules for the use of these neurotechnologies. We believe we are facing a problem that affects human rights, since the brain generates the mind, which defines us as a species. At the end of the day, it is about our essence – our thoughts, perceptions, memories, imagination, emotions and decisions.

To protect citizens from the misuse of these technologies, we have proposed a new set of human rights, called “neurorights.” The most urgent of these to establish is the right to the privacy of our thoughts, since the technologies for reading mental activity are more developed than the technologies for manipulating it.

To defend mental privacy, we are working on a three-pronged approach. The first consists of legislating “neuroprotection.” We believe that data obtained from the brain, which we call “neurodata,” should be rigorously protected by laws similar to those applied to organ donations and transplants. We ask that “neurodata” not be traded and only be extracted with the consent of the individual for medical or scientific purposes.

This would be a preventive measure to protect against abuse. The second approach involves the proposal of proactive ideas; for example, that the companies and organizations that manufacture these technologies should adhere to a code of ethics from the outset, just as doctors do with the Hippocratic Oath. We are working on a “technocratic oath” with Xabi Uribe-Etxebarria, founder of the artificial intelligence company Sherpa.ai, and with the Catholic University of Chile.

The third approach involves engineering, and consists of developing both hardware and software so that brain “neurodata” remains private, and that it is possible to share only select information. The aim is to ensure that the most personal data never leaves the machines that are wired to our brain. One option is to systems that are already used with financial data: open-source files and blockchain technology so that we always know where it came from, and smart contracts to prevent data from getting into the wrong hands. And, of course, it will be necessary to educate the public and make sure that no device can use a person’s data unless he or she authorizes it at that specific time.

Friday, January 4, 2019

Beyond safety questions, gene editing will force us to deal with a moral quandary

Josephine Johnston
STAT News
Originally published November 29, 2018

Here is an excerpt:

The majority of this criticism is motivated by major concerns about safety — we simply do not yet know enough about the impact of CRISPR-Cas9, the powerful new gene-editing tool, to use it create children. But there’s a second, equally pressing concern mixed into many of these condemnations: that gene-editing human eggs, sperm, or embryos is morally wrong.

That moral claim may prove more difficult to resolve than the safety questions, because altering the genomes of future persons — especially in ways that can be passed on generation after generation — goes against international declarations and conventions, national laws, and the ethics codes of many scientific organizations. It also just feels wrong to many people, akin to playing God.

As a bioethicist and a lawyer, I am in no position to say whether CRISPR will at some point prove safe and effective enough to justify its use in human reproductive cells or embryos. But I am willing to predict that blanket prohibitions on permanent changes to the human genome will not stand. When those prohibitions fall — as today’s announcement from the Second International Summit on Human Genome Editing suggests they will — what ethical guideposts or moral norms should replace them?

The info is here.

Sunday, November 4, 2018

When Tech Knows You Better Than You Know Yourself

Nicholas Thompson
www.wired.com
Originally published October 4, 2018

Here is an excerpt:

Hacking a Human

NT: Explain what it means to hack a human being and why what can be done now is different from what could be done 100 years ago.

YNH: To hack a human being is to understand what's happening inside you on the level of the body, of the brain, of the mind, so that you can predict what people will do. You can understand how they feel and you can, of course, once you understand and predict, you can usually also manipulate and control and even replace. And of course it can't be done perfectly and it was possible to do it to some extent also a century ago. But the difference in the level is significant. I would say that the real key is whether somebody can understand you better than you understand yourself. The algorithms that are trying to hack us, they will never be perfect. There is no such thing as understanding perfectly everything or predicting everything. You don't need perfect, you just need to be better than the average human being.

If you have an hour, please watch the video.

Thursday, July 5, 2018

Crispr Fans Fight for Egalitarian Access to Gene Editing

Megan Molteni
Wired.com
Originally posted June 6, 2018

Here is an excerpt:

Like any technology, the applications of gene editing tech will be shaped by the values of the societies that wield it. Which is why a conversation about equitable access to Crispr quickly becomes a conversation about redistributing some of the wealth and education that has been increasingly concentrated in smaller and smaller swaths of the population over the past three decades. Today the richest 1 percent of US families control a record-high 38.6 percent of the country’s wealth. The fear is that Crispr won’t disrupt current inequalities, it’ll just perpetuate them.

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CrisprCon excels at providing a platform to raise these kinds of big picture problems and moral quagmires. But in its second year, it was still light on solutions. The most concrete examples came from a panel of people pursuing ecotechnologies—genetic methods for changing, controlling, or even exterminating species in the wild (disclosure: I moderated the panel).

The information is here.

Friday, April 27, 2018

The Mind-Expanding Ideas of Andy Clark

Larissa MacFarquhar
The New Yorker
Originally published April 2, 2018

Here is an excerpt:

Cognitive science addresses philosophical questions—What is a mind? What is the mind’s relationship to the body? How do we perceive and make sense of the outside world?—but through empirical research rather than through reasoning alone. Clark was drawn to it because he’s not the sort of philosopher who just stays in his office and contemplates; he likes to visit labs and think about experiments. He doesn’t conduct experiments himself; he sees his role as gathering ideas from different places and coming up with a larger theoretical framework in which they all fit together. In physics, there are both experimental and theoretical physicists, but there are fewer theoretical neuroscientists or psychologists—you have to do experiments, for the most part, or you can’t get a job. So in cognitive science this is a role that philosophers can play.

Most people, he realizes, tend to identify their selves with their conscious minds. That’s reasonable enough; after all, that is the self they know about. But there is so much more to cognition than that: the vast, silent cavern of underground mental machinery, with its tubes and synapses and electric impulses, so many unconscious systems and connections and tricks and deeply grooved pathways that form the pulsing substrate of the self. It is those primal mechanisms, the wiring and plumbing of cognition, that he has spent most of his career investigating. When you think about all that fundamental stuff—some ancient and shared with other mammals and distant ancestors, some idiosyncratic and new—consciousness can seem like a merely surface phenomenon, a user interface that obscures the real works below.

The article and audio file are here.

Tuesday, March 27, 2018

Neuroblame?

Stephen Rainey
Practical Ethics
Originally posted February 15, 2018

Here is an excerpt:

Rather than bio-mimetic prostheses, replacement limbs and so on, we can predict that technologies superior to the human body will be developed. Controlled by the brains of users, these enhancements will amount to extensions of the human body, and allow greater projection of human will and intentions in the world. We might imagine a cohort of brain controlled robots carrying out mundane tasks around the home, or buying groceries and so forth, all while the user gets on with something altogether more edifying (or does nothing at all but trigger and control their bots). Maybe a highly skilled, and well-practised, user could control legions of such bots, each carrying out separate tasks.

Before getting too carried away with this line of thought, it’s probably worth getting to the point. The issue worth looking at concerns what happens when things go wrong. It’s one thing to imagine someone sending out a neuro-controlled assassin-bot to kill a rival. Regardless of the unusual route taken, this would be a pretty simple case of causing harm. It would be akin to someone simply assassinating their rival with their own hands. However, it’s another thing to consider how sloppily framing the goal for a bot, such that it ends up causing harm, ought to be parsed.

The blog post is here.

Thursday, January 18, 2018

Humans 2.0: meet the entrepreneur who wants to put a chip in your brain

Zofia Niemtus
The Guardian
Originally posted December 14, 2017

Here are two exerpts:

The shape that this technology will take is still unknown. Johnson uses the term “brain chip”, but the developments taking place in neuroprosthesis are working towards less invasive procedures than opening up your skull and cramming a bit of hardware in; injectable sensors are one possibility.

It may sound far-fetched, but Johnson has a track record of getting things done. Within his first semester at university, he’d set up a profitable business selling mobile phones to fellow students. By age 30, he’d founded online payment company Braintree, which he sold six years later to PayPal for $800m. He used $100m of the proceeds to create Kernel in 2016 – it now employs more than 30 people.

(cut)

“And yet, the brain is everything we are, everything we do, and everything we aspire to be. It seemed obvious to me that the brain is both the most consequential variable in the world and also our biggest blind spot as a species. I decided that if the root problems of humanity begin in the human mind, let’s change our minds.”

The article is here.

Sunday, October 1, 2017

Future Frankensteins: The Ethics of Genetic Intervention

Philip Kitcher
Los Angeles Review of Books
Originally posted September 4, 2017

Here is an excerpt:

The more serious argument perceives risks involved in germline interventions. Human knowledge is partial, and so perhaps we will fail to recognize some dire consequence of eliminating a particular sequence from the genomes of all members of our species. Of course, it is very hard to envisage what might go wrong — in the course of human evolution, many DNA sequences have arisen and disappeared. Moreover, in this instance, assuming a version of CRISPR-Cas9 sufficiently reliable to use on human beings, we could presumably undo whatever damage we had done. But, a skeptic may inquire, why take any risk at all? Surely somatic interventions will suffice. No need to tamper with the germline, since we can always modify the bodies of the unfortunate people afflicted with troublesome sequences.

Doudna and Sternberg point out, in a different context, one reason why this argument fails: some genes associated with disease act too early in development (in utero, for example). There is a second reason for failure. In a world in which people are regularly rescued through somatic interventions, the percentage of later generations carrying problematic sequences is likely to increase, with the consequence that ever more resources would have to be devoted to editing the genomes of individuals.  Human well-being might be more effectively promoted through a program of germline intervention, freeing those resources to help those who suffer in other ways. Once again, allowing editing of eggs and sperm seems to be the path of compassion. (The problems could be mitigated if genetic testing and in vitro fertilization were widely available and widely used, leaving somatic interventions as a last resort for those who slipped through the cracks. But extensive medical resources would still be required, and encouraging — or demanding — pre-natal testing and use of IVF would introduce a problematic and invasive form of eugenics.)

The article is here.

Monday, September 25, 2017

Science debate: Should we embrace an enhanced future?

Alexander Lees
BBC.com
Originally posted September 9, 2017

Here is an excerpt:

Are we all enhanced?

Most humans are now enhanced to be resistant to many infectious diseases. Vaccination is human enhancement. Apart from "anti-vaxxers" - as those who lobby against childhood inoculations are often dubbed - most of us are content to participate. And society as a whole benefits from being free of those diseases.

So what if we took that a pharmaceutical step further. What if, as well as vaccines against polio, mumps, measles, rubella and TB, everyone also "upgraded" by taking drugs to modify their behaviour? Calming beta-blocker drugs could reduce aggression - perhaps even helping to diffuse racial tension. Or what if we were all prescribed the hormone oxytocin, a substance known to enhance social and family bonds - to just help us all just get along a little better.

Would society function better with these chemical tweaks? And might those who opt out become pariahs for not helping to build a better world - for not wanting to be "vaccinated" against anti-social behaviours?

And what if such chemical upgrades could not be made available to everyone, because of cost or scarcity? Should they be available to no one? An enhanced sense of smell might be useful for a career in wine tasting but not perhaps in rubbish disposal.

A case in point is military research - an arm of which is already an ongoing transhumanism experiment.

Many soldiers on the battlefield routinely take pharmaceuticals as cognitive enhancers to reduce the need to sleep and increase the ability to operate under stress. High tech exoskeletons, increasing strength and endurance, are no longer the realms of science fiction and could soon be in routine military use.

The article is here.

New class of drugs targets aging to help keep you healthy

Jacqueline Howard
CNN.com
Originally published September 5, 2017

Here is an excerpt:

"In the coming decades, I believe that health care will be transformed by this class of medicine and a whole set of diseases that your parents and grandparents have will be things you only see in movies or read in books, things like age-associated arthritis," said David, whose company was not involved in the new paper.

Yet he cautioned that, while many more studies may be on the horizon for senolytic drugs, some might not be successful.

"One thing that people tend to do is, they tend to overestimate things in the short run but then underestimate things in the long run, and I think that, like many fields, this suffers from that as well," David said.

"It will take a while," he said. "I think it's important to recognize that a drug discovery is among the most important of all human activities ... but it takes time, and there must be a recognition of that, and it takes patience."

The article is here.

Sunday, August 27, 2017

Super-intelligence and eternal life

Transhumanism’s faithful follow it blindly into a future for the elite

Alexander Thomas
The Conversation
First published July 31, 2017

The rapid development of so-called NBIC technologies – nanotechnology, biotechnology, information technology and cognitive science – are giving rise to possibilities that have long been the domain of science fiction. Disease, ageing and even death are all human realities that these technologies seek to end.

They may enable us to enjoy greater “morphological freedom” – we could take on new forms through prosthetics or genetic engineering. Or advance our cognitive capacities. We could use brain-computer interfaces to link us to advanced artificial intelligence (AI).

Nanobots could roam our bloodstream to monitor our health and enhance our emotional propensities for joy, love or other emotions. Advances in one area often raise new possibilities in others, and this “convergence” may bring about radical changes to our world in the near-future.

“Transhumanism” is the idea that humans should transcend their current natural state and limitations through the use of technology – that we should embrace self-directed human evolution. If the history of technological progress can be seen as humankind’s attempt to tame nature to better serve its needs, transhumanism is the logical continuation: the revision of humankind’s nature to better serve its fantasies.

The article is here.

Friday, June 30, 2017

Ethical Interventions Means Giving Consumers A Say

Susan Liautaud
Wired Magazine
Originally published June 12, 2017

Here is an excerpt:

Increasingly, the people and companies with the technological or scientific ability to create new products or innovations are de facto making policy decisions that affect human safety and society. But these decisions are often based on the creator’s intent for the product, and they don't always take into account its potential risks and unforeseen uses. What if gene-editing is diverted for terrorist ends? What if human-pig chimeras mate? What if citizens prefer to see birds rather than flying cars when they look out a window? (Apparently, this is a real risk. Uber plans to offer flight-hailing apps by 2020.) What if Echo Look leads to mental health issues for teenagers? Who bears responsibility for the consequences?

Jennifer Doudna and Emmanuelle Charpentier’s landmark 2014 article in Science, “The new frontier of genome engineering with CRISPR-Cas9,” called for a broader discussion among “scientists and society at large” about the technology's responsible use. Other leading scientists have joined the call for caution before the technique is intentionally used to alter the human germ line. The National Academies of Science, Engineering, and Medicine recently issued a report recommending that the ethical framework applied to gene therapy also be used when considering Crispr applications. In effect, the experts ask whether their scientific brilliance should legitimize them as decision-makers for all of us.

Crispr might prevent Huntington’s disease and cure cancer. But should errors occur, it’s hard to predict the outcome or prevent its benign use (by thoughtful and competent people) or misuse (by ill-intentioned actors).

Who should decide how Crispr should be used: Scientists? Regulators? Something in between, such as an academic institution, medical research establishment, or professional/industry association? The public? Which public, given the global impact of the decisions? Are ordinary citizens equipped to make such technologically complex ethical decisions? Who will inform the decision-makers about possible risks and benefits?

The article is here.

Thursday, January 19, 2017

Consider ethics when designing new technologies

by Gillian Christie and Derek Yach
Tech Crunch
Originally posted December 31, 2016

Here is an excerpt:

A Fourth Industrial Revolution is arising that will pose tough ethical questions with few simple, black-and-white answers. Smaller, more powerful and cheaper sensors; cognitive computing advancements in artificial intelligence, robotics, predictive analytics and machine learning; nano, neuro and biotechnology; the Internet of Things; 3D printing; and much more, are already demanding real answers really fast. And this will only get harder and more complex when we embed these new technologies into our bodies and brains to enhance our physical and cognitive functioning.

Take the choice society will soon have to make about autonomous cars as an example. If a crash cannot be avoided, should a car be programmed to minimize bystander casualties even if it harms the car’s occupants, or should the car protect its occupants under any circumstances?

Research demonstrates the public is conflicted. Consumers would prefer to minimize the number of overall casualties in a car accident, yet are unwilling to purchase a self-driving car if it is not self-protective. Of course, the ideal option is for companies to develop algorithms that bypass this possibility entirely, but this may not always be an option. What is clear, however, is that such ethical quandaries must be reconciled before any consumer hands over their keys to dark-holed algorithms.

The article is here.

Friday, December 9, 2016

Moral neuroenhancement

Earp, B. D., Douglas, T., & Savulescu, J. (forthcoming). Moral neuroenhancement. In S. Johnson & K. Rommelfanger (eds.),  Routledge Handbook of Neuroethics.  New York: Routledge.

Abstract

In this chapter, we introduce the notion of moral neuroenhancement, offering a novel definition as well as spelling out three conditions under which we expect that such neuroenhancement would be most likely to be permissible (or even desirable). Furthermore, we draw a distinction between first-order moral capacities, which we suggest are less promising targets for neurointervention, and second-order moral capacities, which we suggest are more promising. We conclude by discussing concerns that moral neuroenhancement might restrict freedom or otherwise misfire, and argue that these concerns are not as damning as they may seem at first.

The book chapter is here.

Friday, September 16, 2016

The first autonomous, entirely soft robot

By Leah Burrows
Harvard Gazette
Originally published August 24, 2016

Here are two excerpts:

Soft robotics could help revolutionize how humans interact with machines. But researchers have struggled to build entirely compliant robots. Electric power and control systems — such as batteries and circuit boards — are rigid, and until now soft-bodied robots have been either tethered to an off-board system or rigged with hard components.

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“One longstanding vision for the field of soft robotics has been to create robots that are entirely soft, but the struggle has always been in replacing rigid components like batteries and electronic controls with analogous soft systems and then putting it all together,” said Wood. “This research demonstrates that we can easily manufacture the key components of a simple, entirely soft robot, which lays the foundation for more complex designs.”

The article and video are here.

Sunday, July 20, 2014

In Depth: Should We Design Our Babies?

The Aspen Institute
Streamed live on July 2, 2014

The discussion of "designer babies" often revolves around gender or hair color, but the medical debate is far more complicated. Should we screen embryos for disease or other genetic modifications? These considerations raise ethical questions and call into question the validity of surrounding research. The lack of regulation and oversight make this particular biotechnology frightening to some, while the potential for disease eradicating techniques excites others. But how far is too far? What are the major scientific and ethical hurdles to assuage the skeptics? Underwritten by Booz Allen Hamilton