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Tuesday, September 13, 2022

First synthetic embryos: the scientific breakthrough raises serious ethical questions

Savulescu, J., Gyngell, C., & Sawai, T.
The Conversation
Originally posted 11 AUG 22

Here is an excerpt:

Artificial wombs

In the latest study, the scientists started with collections of stem cells. The conditions created by the external uterus triggered the developmental process that makes a fetus. Although the scientists said we are a long way off synthetic human embryos, the experiment brings us closer to a future where some humans gestate their babies artificially.

Each year over 300,000 women worldwide die in childbirth or as a result of pregnancy complications, many because they lack basic care. Even in wealthy countries, pregnancy and childbirth is risky and healthcare providers are criticised for failing mothers.

There is an urgent need to make healthcare more accessible across the planet, provide better mental health support for mothers and make pregnancy and childbirth safer. In an ideal world every parent should expect excellent care in all aspects of motherhood. This technology could help treat premature babies and give at least some women a different option: a choice of whether to carry their child or use an external uterus.

Some philosophers say there is a moral imperative to develop artificial wombs to help remedy the unfairness of parenting roles. But other researchers say artificial wombs would threaten a women’s legal right to terminate a pregnancy.

Synthetic embryos and organs

In the last few years, scientists have learned more about how to coax stem cells to develop into increasingly sophisticated structures, including ones that mimic the structure and function of human organs (organoids). Artificial human kidneys, brains, hearts and more have all been created in a lab, though they are still too rudimentary for medical use.

The issue of whether there are moral differences between using stem cells to produce models of human organs for research and using stem cells to create a synthetic embryo are already playing out in law courts.

One of the key differences between organoids and synthetic embryos is their potential. If a synthetic embryo can develop into a living creature, it should have more protection than those which don’t.

Synthetic embryos do not currently have potential to actually create a living mouse. If scientists did make human synthetic embryos, but without the potential to form a living being, they should arguably be treated similarly to organoids.