Everything you need to know about artificial wombs

Cassandra Willyard

MIT Technology Review

Originally posted 29 SEPT 23

Here is an excerpt:

What is an artificial womb?

An artificial womb is an experimental medical device intended to provide a womblike environment for extremely premature infants. In most of the technologies, the infant would float in a clear “biobag,” surrounded by fluid. The idea is that preemies could spend a few weeks continuing to develop in this device after birth, so that “when they’re transitioned from the device, they’re more capable of surviving and having fewer complications with conventional treatment,” says George Mychaliska, a pediatric surgeon at the University of Michigan.

One of the main limiting factors for survival in extremely premature babies is lung development. Rather than breathing air, babies in an artificial womb would have their lungs filled with lab-made amniotic fluid, that mimics the amniotic fluid they would have hadjust like they would in utero. Neonatologists would insert tubes into blood vessels in the umbilical cord so that the infant’s blood could cycle through an artificial lung to pick up oxygen. 

The device closest to being ready to be tested in humans, called the EXTrauterine Environment for Newborn Development, or EXTEND, encases the baby in a container filled with lab-made amniotic fluid. It was invented by Alan Flake and Marcus Davey at the Children’s Hospital of Philadelphia and is being developed by Vitara Biomedical.

The info is here.

Here is my take:

Artificial wombs are experimental medical devices that aim to provide a womb-like environment for extremely premature infants. The technology is still in its early stages of development, but it has the potential to save the lives of many babies who would otherwise not survive.

Overall, artificial wombs are a promising new technology with the potential to revolutionize the care of premature infants. However, more research is needed to fully understand the risks and benefits of the technology before it can be widely used.

Here are some additional ethical concerns that have been raised about artificial wombs:

• The potential for artificial wombs to be used to create designer babies or to prolong the lives of fetuses with severe disabilities.
• The potential for artificial wombs to be used to exploit or traffick babies.
• The potential for artificial wombs to exacerbate existing social and economic inequalities.

It is important to have a public conversation about these ethical concerns before artificial wombs become widely available. We need to develop clear guidelines for how the technology should be used and ensure that it is used in a way that benefits all of society.

First synthetic embryos: the scientific breakthrough raises serious ethical questions

Savulescu, J., Gyngell, C., & Sawai, T.

The Conversation

Originally posted 11 AUG 22

Here is an excerpt:

Artificial wombs

In the latest study, the scientists started with collections of stem cells. The conditions created by the external uterus triggered the developmental process that makes a fetus. Although the scientists said we are a long way off synthetic human embryos, the experiment brings us closer to a future where some humans gestate their babies artificially.

Each year over 300,000 women worldwide die in childbirth or as a result of pregnancy complications, many because they lack basic care. Even in wealthy countries, pregnancy and childbirth is risky and healthcare providers are criticised for failing mothers.

There is an urgent need to make healthcare more accessible across the planet, provide better mental health support for mothers and make pregnancy and childbirth safer. In an ideal world every parent should expect excellent care in all aspects of motherhood. This technology could help treat premature babies and give at least some women a different option: a choice of whether to carry their child or use an external uterus.

Some philosophers say there is a moral imperative to develop artificial wombs to help remedy the unfairness of parenting roles. But other researchers say artificial wombs would threaten a women’s legal right to terminate a pregnancy.

Synthetic embryos and organs

In the last few years, scientists have learned more about how to coax stem cells to develop into increasingly sophisticated structures, including ones that mimic the structure and function of human organs (organoids). Artificial human kidneys, brains, hearts and more have all been created in a lab, though they are still too rudimentary for medical use.

The issue of whether there are moral differences between using stem cells to produce models of human organs for research and using stem cells to create a synthetic embryo are already playing out in law courts.

One of the key differences between organoids and synthetic embryos is their potential. If a synthetic embryo can develop into a living creature, it should have more protection than those which don’t.

Synthetic embryos do not currently have potential to actually create a living mouse. If scientists did make human synthetic embryos, but without the potential to form a living being, they should arguably be treated similarly to organoids.

The info is here.