David Cyranoski
Nature
Originally published November 16, 2016
A Chinese group has become the first to inject a person with cells that contain genes edited using the revolutionary CRISPR–Cas9 technique.
On 28 October, a team led by oncologist Lu You at Sichuan University in Chengdu delivered the modified cells into a patient with aggressive lung cancer as part of a clinical trial at the West China Hospital, also in Chengdu.
Earlier clinical trials using cells edited with a different technique have excited clinicians. The introduction of CRISPR, which is simpler and more efficient than other techniques, will probably accelerate the race to get gene-edited cells into the clinic across the world, says Carl June, who specializes in immunotherapy at the University of Pennsylvania in Philadelphia and led one of the earlier studies.
The article is here.
Monday, November 28, 2016
Studying ethics, 'Star Trek' style, at Drake
Daniel P. Finney
The Des Moines Register
Originally posted November 10, 2016
Here is an excerpt:
Sure, the discussion was about ethics of the fictional universe of “Star Trek.” But fiction, like all art, reflects the human condition.
The issue Capt. Sisko wrestled with had parallels to the real world.
Some historians hold the controversial assertion that President Franklin D. Roosevelt knew of the impending attack on Pearl Harbor in 1941 but allowed it to happen to bring the United States into World War II, a move the public opposed before the attack.
In more recent times, former President George W. Bush’s administration used faulty intelligence suggesting Iraq possessed weapons of mass destruction to justify a war that many believed would stabilize the increasingly sectarian Middle East. It did not.
The article is here.
The Des Moines Register
Originally posted November 10, 2016
Here is an excerpt:
Sure, the discussion was about ethics of the fictional universe of “Star Trek.” But fiction, like all art, reflects the human condition.
The issue Capt. Sisko wrestled with had parallels to the real world.
Some historians hold the controversial assertion that President Franklin D. Roosevelt knew of the impending attack on Pearl Harbor in 1941 but allowed it to happen to bring the United States into World War II, a move the public opposed before the attack.
In more recent times, former President George W. Bush’s administration used faulty intelligence suggesting Iraq possessed weapons of mass destruction to justify a war that many believed would stabilize the increasingly sectarian Middle East. It did not.
The article is here.
Sunday, November 27, 2016
Approach-Induced Biases in Human Information Sampling
Laurence T. Hunt and others
PLOS Biology
Published: November 10, 2016
Abstract
Information sampling is often biased towards seeking evidence that confirms one’s prior beliefs. Despite such biases being a pervasive feature of human behavior, their underlying causes remain unclear. Many accounts of these biases appeal to limitations of human hypothesis testing and cognition, de facto evoking notions of bounded rationality, but neglect more basic aspects of behavioral control. Here, we investigated a potential role for Pavlovian approach in biasing which information humans will choose to sample. We collected a large novel dataset from 32,445 human subjects, making over 3 million decisions, who played a gambling task designed to measure the latent causes and extent of information-sampling biases. We identified three novel approach-related biases, formalized by comparing subject behavior to a dynamic programming model of optimal information gathering. These biases reflected the amount of information sampled (“positive evidence approach”), the selection of which information to sample (“sampling the favorite”), and the interaction between information sampling and subsequent choices (“rejecting unsampled options”). The prevalence of all three biases was related to a Pavlovian approach-avoid parameter quantified within an entirely independent economic decision task. Our large dataset also revealed that individual differences in the amount of information gathered are a stable trait across multiple gameplays and can be related to demographic measures, including age and educational attainment. As well as revealing limitations in cognitive processing, our findings suggest information sampling biases reflect the expression of primitive, yet potentially ecologically adaptive, behavioral repertoires. One such behavior is sampling from options that will eventually be chosen, even when other sources of information are more pertinent for guiding future action.
The article is here.
PLOS Biology
Published: November 10, 2016
Abstract
Information sampling is often biased towards seeking evidence that confirms one’s prior beliefs. Despite such biases being a pervasive feature of human behavior, their underlying causes remain unclear. Many accounts of these biases appeal to limitations of human hypothesis testing and cognition, de facto evoking notions of bounded rationality, but neglect more basic aspects of behavioral control. Here, we investigated a potential role for Pavlovian approach in biasing which information humans will choose to sample. We collected a large novel dataset from 32,445 human subjects, making over 3 million decisions, who played a gambling task designed to measure the latent causes and extent of information-sampling biases. We identified three novel approach-related biases, formalized by comparing subject behavior to a dynamic programming model of optimal information gathering. These biases reflected the amount of information sampled (“positive evidence approach”), the selection of which information to sample (“sampling the favorite”), and the interaction between information sampling and subsequent choices (“rejecting unsampled options”). The prevalence of all three biases was related to a Pavlovian approach-avoid parameter quantified within an entirely independent economic decision task. Our large dataset also revealed that individual differences in the amount of information gathered are a stable trait across multiple gameplays and can be related to demographic measures, including age and educational attainment. As well as revealing limitations in cognitive processing, our findings suggest information sampling biases reflect the expression of primitive, yet potentially ecologically adaptive, behavioral repertoires. One such behavior is sampling from options that will eventually be chosen, even when other sources of information are more pertinent for guiding future action.
The article is here.
Saturday, November 26, 2016
Harvard scientists think they've pinpointed the physical source of consciousness
Fiona McDonald
Sciencealert.com
Originally posted 8 November 2016
Here is an excerpt:
Now the Harvard team has identified not only the specific brainstem region linked to arousal, but also two cortex regions, that all appear to work together to form consciousness.
To figure this out, the team analysed 36 patients in hospital with brainstem lesions - 12 of them were in a coma (unconscious) and 24 were defined as being conscious.
The researchers then mapped their brainstems to figure out if there was one particular region that could explain why some patients had maintained consciousness despite their injuries, while others had become comatose.
What they found was one small area of the brainstem - known as the rostral dorsolateral pontine tegmentum - that was significantly associated with coma. Ten out of the 12 unconscious patients had damage in this area, while just one out of the 24 conscious patients did.
The article is here.
Sciencealert.com
Originally posted 8 November 2016
Here is an excerpt:
Now the Harvard team has identified not only the specific brainstem region linked to arousal, but also two cortex regions, that all appear to work together to form consciousness.
To figure this out, the team analysed 36 patients in hospital with brainstem lesions - 12 of them were in a coma (unconscious) and 24 were defined as being conscious.
The researchers then mapped their brainstems to figure out if there was one particular region that could explain why some patients had maintained consciousness despite their injuries, while others had become comatose.
What they found was one small area of the brainstem - known as the rostral dorsolateral pontine tegmentum - that was significantly associated with coma. Ten out of the 12 unconscious patients had damage in this area, while just one out of the 24 conscious patients did.
The article is here.
What is data ethics?
Luciano Floridi and Mariarosaria Taddeo
Philosophical Transactions Royal Society A
This theme issue has the founding ambition of landscaping data ethics as a new branch of ethics that studies and evaluates moral problems related to data (including generation, recording, curation, processing, dissemination, sharing and use), algorithms (including artificial intelligence, artificial agents, machine learning and robots) and corresponding practices (including responsible innovation, programming, hacking and professional codes), in order to formulate and support morally good solutions (e.g. right conducts or right values). Data ethics builds on the foundation provided by computer and information ethics but, at the sametime, it refines the approach endorsed so far in this research field, by shifting the level of abstraction of ethical enquiries, from being information-centric to being data-centric. This shift brings into focus the different moral dimensions of all kinds of data, even data that never translate directly into information but can be used to support actions or generate behaviours, for example. It highlights the need for ethical analyses to concentrate on the content and nature of computational operations—the interactions among hardware, software and data—rather than on the variety of digital technologies that enable them. And it emphasizes the complexity of the ethical challenges posed by data science. Because of such complexity, data ethics should be developed from the start as a macroethics, that is, as an overall framework that avoids narrow, ad hoc approaches and addresses the ethical impact and implications of data science and its applications within a consistent, holistic and inclusive framework. Only as a macroethics will data ethics provide solutions that can maximize the value of data science for our societies, for all of us and for our environments.This article is part of the themed issue ‘The ethical impact of data science’.
The article is here.
Philosophical Transactions Royal Society A
This theme issue has the founding ambition of landscaping data ethics as a new branch of ethics that studies and evaluates moral problems related to data (including generation, recording, curation, processing, dissemination, sharing and use), algorithms (including artificial intelligence, artificial agents, machine learning and robots) and corresponding practices (including responsible innovation, programming, hacking and professional codes), in order to formulate and support morally good solutions (e.g. right conducts or right values). Data ethics builds on the foundation provided by computer and information ethics but, at the sametime, it refines the approach endorsed so far in this research field, by shifting the level of abstraction of ethical enquiries, from being information-centric to being data-centric. This shift brings into focus the different moral dimensions of all kinds of data, even data that never translate directly into information but can be used to support actions or generate behaviours, for example. It highlights the need for ethical analyses to concentrate on the content and nature of computational operations—the interactions among hardware, software and data—rather than on the variety of digital technologies that enable them. And it emphasizes the complexity of the ethical challenges posed by data science. Because of such complexity, data ethics should be developed from the start as a macroethics, that is, as an overall framework that avoids narrow, ad hoc approaches and addresses the ethical impact and implications of data science and its applications within a consistent, holistic and inclusive framework. Only as a macroethics will data ethics provide solutions that can maximize the value of data science for our societies, for all of us and for our environments.This article is part of the themed issue ‘The ethical impact of data science’.
The article is here.
Friday, November 25, 2016
A New Spin on the Quantum Brain
By Jennifer Ouellette
Quanta Magazine
November 2, 2016
The mere mention of “quantum consciousness” makes most physicists cringe, as the phrase seems to evoke the vague, insipid musings of a New Age guru. But if a new hypothesis proves to be correct, quantum effects might indeed play some role in human cognition. Matthew Fisher, a physicist at the University of California, Santa Barbara, raised eyebrows late last year when he published a paper in Annals of Physics proposing that the nuclear spins of phosphorus atoms could serve as rudimentary “qubits” in the brain — which would essentially enable the brain to function like a quantum computer.
As recently as 10 years ago, Fisher’s hypothesis would have been dismissed by many as nonsense. Physicists have been burned by this sort of thing before, most notably in 1989, when Roger Penrose proposed that mysterious protein structures called “microtubules” played a role in human consciousness by exploiting quantum effects. Few researchers believe such a hypothesis plausible. Patricia Churchland, a neurophilosopher at the University of California, San Diego, memorably opined that one might as well invoke “pixie dust in the synapses” to explain human cognition.
The article is here.
Quanta Magazine
November 2, 2016
The mere mention of “quantum consciousness” makes most physicists cringe, as the phrase seems to evoke the vague, insipid musings of a New Age guru. But if a new hypothesis proves to be correct, quantum effects might indeed play some role in human cognition. Matthew Fisher, a physicist at the University of California, Santa Barbara, raised eyebrows late last year when he published a paper in Annals of Physics proposing that the nuclear spins of phosphorus atoms could serve as rudimentary “qubits” in the brain — which would essentially enable the brain to function like a quantum computer.
As recently as 10 years ago, Fisher’s hypothesis would have been dismissed by many as nonsense. Physicists have been burned by this sort of thing before, most notably in 1989, when Roger Penrose proposed that mysterious protein structures called “microtubules” played a role in human consciousness by exploiting quantum effects. Few researchers believe such a hypothesis plausible. Patricia Churchland, a neurophilosopher at the University of California, San Diego, memorably opined that one might as well invoke “pixie dust in the synapses” to explain human cognition.
The article is here.
Thursday, November 24, 2016
Middle School Suicides Reach An All-Time High
Elissa Nadworny
npr.com
Originally posted November 4, 2016
There's a perception that children don't kill themselves, but that's just not true. A new report shows that, for the first time, suicide rates for U.S. middle school students have surpassed the rate of death by car crashes.
The suicide rate among youngsters ages 10 to 14 has been steadily rising, and doubled in the U.S. from 2007 to 2014, according to the Centers for Disease Control and Prevention. In 2014, 425 young people 10 to 14 years of age died by suicide.
The article and the video are here.
National Suicide Hotline: 1-800-273-8255
npr.com
Originally posted November 4, 2016
There's a perception that children don't kill themselves, but that's just not true. A new report shows that, for the first time, suicide rates for U.S. middle school students have surpassed the rate of death by car crashes.
The suicide rate among youngsters ages 10 to 14 has been steadily rising, and doubled in the U.S. from 2007 to 2014, according to the Centers for Disease Control and Prevention. In 2014, 425 young people 10 to 14 years of age died by suicide.
The article and the video are here.
National Suicide Hotline: 1-800-273-8255
Wednesday, November 23, 2016
Increase in US Suicide Rates and the Critical Decline in Psychiatric Beds
Tarun Bastiampillai, Steven S. Sharfstein, & Stephen Allison
JAMA. Published online November 3, 2016
The closure of most US public mental hospital beds and the reduction in acute general psychiatric beds over recent decades have led to a crisis, as overall inpatient capacity has not kept pace with the needs of patients with psychiatric disorders. Currently, state-funded psychiatric beds are almost entirely forensic (ie, allocated to people within the criminal justice system who have been charged or convicted). Very limited access to nonforensic psychiatric inpatient care is contributing to the risks of violence, incarceration, homelessness, premature mortality, and suicide among patients with psychiatric disorders. In particular, a safe minimum number of psychiatric beds is required to respond to suicide risk given the well-established and unchanging prevalence of mental illness, relapse rates, treatment resistance, nonadherence with treatment, and presentations after acute social crisis. Very limited access to inpatient care is likely a contributing factor for the increasing US suicide rate. In 2014, suicide was the second-leading cause of death for people aged between 10 and 34 years and the tenth-leading cause of death for all age groups, with firearm trauma being the leading method.
Currently, the United States has a relatively low 22 psychiatric beds per 100 000 population compared with the Organisation for Economic Cooperation and Development (OECD) average of 71 beds per 100 000 population. Only 4 of the 35 OECD countries (Italy, Chile, Turkey, and Mexico) have fewer psychiatric beds per 100 000 population than the United States. Although European health systems are very different from the US health system, they provide a useful comparison. For instance, Germany, Switzerland, and France have 127, 91, and 87 psychiatric beds per 100 000 population, respectively.
The article is here.
JAMA. Published online November 3, 2016
The closure of most US public mental hospital beds and the reduction in acute general psychiatric beds over recent decades have led to a crisis, as overall inpatient capacity has not kept pace with the needs of patients with psychiatric disorders. Currently, state-funded psychiatric beds are almost entirely forensic (ie, allocated to people within the criminal justice system who have been charged or convicted). Very limited access to nonforensic psychiatric inpatient care is contributing to the risks of violence, incarceration, homelessness, premature mortality, and suicide among patients with psychiatric disorders. In particular, a safe minimum number of psychiatric beds is required to respond to suicide risk given the well-established and unchanging prevalence of mental illness, relapse rates, treatment resistance, nonadherence with treatment, and presentations after acute social crisis. Very limited access to inpatient care is likely a contributing factor for the increasing US suicide rate. In 2014, suicide was the second-leading cause of death for people aged between 10 and 34 years and the tenth-leading cause of death for all age groups, with firearm trauma being the leading method.
Currently, the United States has a relatively low 22 psychiatric beds per 100 000 population compared with the Organisation for Economic Cooperation and Development (OECD) average of 71 beds per 100 000 population. Only 4 of the 35 OECD countries (Italy, Chile, Turkey, and Mexico) have fewer psychiatric beds per 100 000 population than the United States. Although European health systems are very different from the US health system, they provide a useful comparison. For instance, Germany, Switzerland, and France have 127, 91, and 87 psychiatric beds per 100 000 population, respectively.
The article is here.
Moral Distress in Physicians and Nurses: Impact on Professional Quality of Life and Turnover.
C. L. Austin, R. Saylor, and P. J. Finley
Psychological Trauma: Theory, Research, Practice, and Policy, 2016
Abstract
Objective: The purpose of this study was to investigate moral distress (MD) and turnover intent as related to professional quality of life in physicians and nurses at a tertiary care hospital.
Method: Health care providers from a variety of hospital departments anonymously completed 2 validated questionnaires (Moral Distress Scale–Revised and Professional Quality of Life Scale). Compassion fatigue (as measured by secondary traumatic stress [STS] and burnout [BRN]) and compassion satisfaction are subscales which make up one’s professional quality of life. Relationships between these constructs and clinicians’ years in health care, critical care patient load, and professional discipline were explored.
Results: The findings (n = 329) demonstrated significant correlations between STS, BRN, and MD. Scores associated with intentions to leave or stay in a position were indicative of high verses low MD. We report highest scoring situations of MD as well as when physicians and nurses demonstrate to be most at risk for STS, BRN and MD. Both physicians and nurses identified the events contributing to the highest level of MD as being compelled to provide care that seems ineffective and working with a critical care patient load >50%.
Conclusion: The results from this study of physicians and nurses suggest that the presence of MD significantly impacts turnover intent and professional quality of life. Therefore implementation of emotional wellness activities (e.g., empowerment, opportunity for open dialog regarding ethical dilemmas, policy making involvement) coupled with ongoing monitoring and routine assessment of these maladaptive characteristics is warranted.
The article is here.
Psychological Trauma: Theory, Research, Practice, and Policy, 2016
Abstract
Objective: The purpose of this study was to investigate moral distress (MD) and turnover intent as related to professional quality of life in physicians and nurses at a tertiary care hospital.
Method: Health care providers from a variety of hospital departments anonymously completed 2 validated questionnaires (Moral Distress Scale–Revised and Professional Quality of Life Scale). Compassion fatigue (as measured by secondary traumatic stress [STS] and burnout [BRN]) and compassion satisfaction are subscales which make up one’s professional quality of life. Relationships between these constructs and clinicians’ years in health care, critical care patient load, and professional discipline were explored.
Results: The findings (n = 329) demonstrated significant correlations between STS, BRN, and MD. Scores associated with intentions to leave or stay in a position were indicative of high verses low MD. We report highest scoring situations of MD as well as when physicians and nurses demonstrate to be most at risk for STS, BRN and MD. Both physicians and nurses identified the events contributing to the highest level of MD as being compelled to provide care that seems ineffective and working with a critical care patient load >50%.
Conclusion: The results from this study of physicians and nurses suggest that the presence of MD significantly impacts turnover intent and professional quality of life. Therefore implementation of emotional wellness activities (e.g., empowerment, opportunity for open dialog regarding ethical dilemmas, policy making involvement) coupled with ongoing monitoring and routine assessment of these maladaptive characteristics is warranted.
The article is here.
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