Welcome to the Nexus of Ethics, Psychology, Morality, Philosophy and Health Care

Welcome to the nexus of ethics, psychology, morality, technology, health care, and philosophy
Showing posts with label Chimera. Show all posts
Showing posts with label Chimera. Show all posts

Monday, January 1, 2024

Cyborg computer with living brain organoid aces machine learning tests

Loz Blain
New Atlas
Originally posted 12 DEC 23

Here are two excerpts:

Now, Indiana University researchers have taken a slightly different approach by growing a brain "organoid" and mounting that on a silicon chip. The difference might seem academic, but by allowing the stem cells to self-organize into a three-dimensional structure, the researchers hypothesized that the resulting organoid might be significantly smarter, that the neurons might exhibit more "complexity, connectivity, neuroplasticity and neurogenesis" if they were allowed to arrange themselves more like the way they normally do.

So they grew themselves a little brain ball organoid, less than a nanometer in diameter, and they mounted it on a high-density multi-electrode array – a chip that's able to send electrical signals into the brain organoid, as well as reading electrical signals that come out due to neural activity.

They called it "Brainoware" – which they probably meant as something adjacent to hardware and software, but which sounds far too close to "BrainAware" for my sensitive tastes, and evokes the perpetual nightmare of one of these things becoming fully sentient and understanding its fate.

(cut)

And finally, much like the team at Cortical Labs, this team really has no clear idea what to do about the ethics of creating micro-brains out of human neurons and wiring them into living cyborg computers. “As the sophistication of these organoid systems increases, it is critical for the community to examine the myriad of neuroethical issues that surround biocomputing systems incorporating human neural tissue," wrote the team. "It may be decades before general biocomputing systems can be created, but this research is likely to generate foundational insights into the mechanisms of learning, neural development and the cognitive implications of neurodegenerative diseases."


Here is my summary:

There is a new type of computer chip that uses living brain cells. The brain cells are grown from human stem cells and are organized into a ball-like structure called an organoid. The organoid is mounted on a chip that can send electrical signals to the brain cells and read the electrical signals that the brain cells produce. The researchers found that the organoid could learn to perform tasks such as speech recognition and math prediction much faster than traditional computers. They believe that this new type of computer chip could have many applications, such as in artificial intelligence and medical research. However, there are also some ethical concerns about using living brain cells in computers.

Tuesday, May 4, 2021

Human cells grown in monkey embryos reignite ethics debate

Nicola Davis
The Guardian
Originally published 15 Apr 21

Monkey embryos containing human cells have been produced in a laboratory, a study has confirmed, spurring fresh debate into the ethics of such experiments.

The embryos are known as chimeras, organisms whose cells come from two or more “individuals”, and in this case, different species: a long-tailed macaque and a human.

In recent years researchers have produced pig embryos and sheep embryos that contain human cells – research they say is important as it could one day allow them to grow human organs inside other animals, increasing the number of organs available for transplant.

Now scientists have confirmed they have produced macaque embryos that contain human cells, revealing the cells could survive and even multiply.

In addition, the researchers, led by Prof Juan Carlos Izpisua Belmonte from the Salk Institute in the US, said the results offer new insight into communications pathways between cells of different species: work that could help them with their efforts to make chimeras with species that are less closely related to our own.

“These results may help to better understand early human development and primate evolution and develop effective strategies to improve human chimerism in evolutionarily distant species,” the authors wrote.

The study confirms rumours reported in the Spanish newspaper El País in 2019 that a team of researchers led by Belmonte had produced monkey-human chimeras. The word chimera comes from a beast in Greek mythology that was said to be part lion, part goat and part snake.

Thursday, August 15, 2019

World’s first ever human-monkey hybrid grown in lab in China

Henry Holloway
www.dailystar.co.uk
Originally posted August 1, 2019

Here is an excerpt:

Scientists have successfully formed a hybrid human-monkey embryo  – with the experiment taking place in China to avoid “legal issues”.

Researchers led by scientist Juan Carlos Izpisúa spliced together the genes to grow a monkey with human cells.

It is said the creature could have grown and been born, but scientists aborted the process.

The team, made up of members of the Salk Institute in the United States and the Murcia Catholic University, genetically modified the monkey embryos.

Researchers deactivates the genes which form organs, and replaced them with human stem cells.

And it is hoped that one day these hybrid-grown organs will be able to be translated into humans.

Scientists have successfully formed a hybrid human-monkey embryo  – with the experiment taking place in China to avoid “legal issues”.

Researchers led by scientist Juan Carlos Izpisúa spliced together the genes to grow a monkey with human cells.

It is said the creature could have grown and been born, but scientists aborted the process.

The info is here.

Monday, July 29, 2019

Experts question the morality of creating human-monkey ‘chimeras’

Kay Vandette
www.earth.com
Originally published July 5, 2019

Earlier this year, scientists at the Kunming Institute of Zoology of the Chinese Academy of Sciences announced they had inserted a human gene into embryos that would become rhesus macaques, monkeys that share about 93 percent of their DNA with humans. The research, which was designed to give experts a better understanding of human brain development, has sparked controversy over whether this type of experimentation is ethical.

Some scientists believe that it is time to use human-monkey animals to pursue new insights into the progression of diseases such as Alzheimer’s. These genetically modified monkeys are referred to as chimeras, which are named after a mythical animal that consists of parts taken from various animals.

A resource guide on the science and ethics of chimeras written by Yale University researchers suggests that it is time to “cautiously” explore the creation of human-monkey chimeras.

“The search for a better animal model to stimulate human disease has been a ‘holy grail’ of biomedical research for decades,” the Yale team wrote in Chimera Research: Ethics and Protocols. “Realizing the promise of human-monkey chimera research in an ethically and scientifically appropriate manner will require a coordinated approach.”

A team of experts led by Dr. Douglas Munoz of Queen’s University has been studying the onset of Alzheimer’s disease in monkeys by using injections of beta-amyloid. The accumulation of this protein in the brain is believed to kill nerve cells and initiate the degenerative process.

The info is here.

Wednesday, May 1, 2019

Chinese scientists create super monkeys by injecting brains with human DNA

Harriet Brewis
www.msn.com
Originally published April 13, 2019

Chinese scientists have created super-intelligent monkeys by injecting them with human DNA.

Researchers transferred a gene linked to brain development, called MCPH1, into rhesus monkey embryos.

Once they were born, the monkeys were found to have better memories, reaction times and processing abilities than their untouched peers.

"This was the first attempt to understand the evolution of human cognition using a transgenic monkey model," said Bing Su, a geneticist at Kunming Institute of Zoology in China.

The research was conducted by Dr Su’s team at the Kunming Institute of Zoology, in collaboration with the Chinese Academy of Sciences and University of North Carolina in the US.

“Our findings demonstrated that nonhuman primates (excluding ape species) have the potential to provide important – and potentially unique – insights into basic questions of what actually makes human unique,” the authors wrote in the study.

The info is here.

Monday, May 28, 2018

The ethics of experimenting with human brain tissue

Nita Farahany, and others
Nature
Originally published April 25, 2018

If researchers could create brain tissue in the laboratory that might appear to have conscious experiences or subjective phenomenal states, would that tissue deserve any of the protections routinely given to human or animal research subjects?

This question might seem outlandish. Certainly, today’s experimental models are far from having such capabilities. But various models are now being developed to better understand the human brain, including miniaturized, simplified versions of brain tissue grown in a dish from stem cells — brain organoids. And advances keep being made.

These models could provide a much more accurate representation of normal and abnormal human brain function and development than animal models can (although animal models will remain useful for many goals). In fact, the promise of brain surrogates is such that abandoning them seems itself unethical, given the vast amount of human suffering caused by neurological and psychiatric disorders, and given that most therapies for these diseases developed in animal models fail to work in people. Yet the closer the proxy gets to a functioning human brain, the more ethically problematic it becomes.

The information is here.


Saturday, March 24, 2018

Breakthrough as scientists grow sheep embryos containing human cells

Nicola Davis
The Guardian
Originally published February 17, 2018

Growing human organs inside other animals has taken another step away from science-fiction, with researchers announcing they have grown sheep embryos containing human cells.

Scientists say growing human organs inside animals could not only increase supply, but also offer the possibility of genetically tailoring the organs to be compatible with the immune system of the patient receiving them, by using the patient’s own cells in the procedure, removing the possibility of rejection.

According to NHS Blood and Transplant, almost 460 people died in 2016 waiting for organs, while those who do receive transplants sometimes see organs rejected.

“Even today the best matched organs, except if they come from identical twins, don’t last very long because with time the immune system continuously is attacking them,” said Dr Pablo Ross from the University of California, Davis, who is part of the team working towards growing human organs in other species.

Ross added that if it does become possible to grow human organs inside other species, it might be that organ transplants become a possibility beyond critical conditions.

The information is here.