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Showing posts with label Retractions. Show all posts
Showing posts with label Retractions. Show all posts

Monday, August 7, 2023

Shake-up at top psychiatric institute following suicide in clinical trial

Brendan Borrell
Spectrum News
Originally posted 31 July 23

Here are two excerpts:

The audit and turnover in leadership comes after the halting of a series of clinical trials conducted by Columbia psychiatrist Bret Rutherford, which tested whether the drug levodopa — typically used to treat Parkinson’s disease — could improve mood and mobility in adults with depression.

During a double-blind study that began in 2019, a participant in the placebo group died by suicide. That study was suspended prior to completion, according to an update posted on ClinicalTrials.gov in 2022.

Two published reports based on Rutherford’s pilot studies have since been retracted, as Spectrum has previously reported. The National Institute of Mental Health has terminated Rutherford’s trials and did not renew funding of his research grant or K24 Midcareer Award.

Former members of Rutherford’s laboratory describe it as a high-pressure environment that often put publications ahead of study participants. “Research is important, but not more so than the lives of those who participate in it,” says Kaleigh O’Boyle, who served as clinical research coordinator there from 2018 to 2020.

Although Rutherford’s faculty page is still active, he is no longer listed in the directory at Columbia University, where he was associate professor, and the voicemail at his former number says he is no longer checking it. He did not respond to voicemails and text messages sent to his personal phone or to emails sent to his Columbia email address, and Cantor would not comment on his employment status.

The circumstances around the suicide remain unclear, and the institute has previously declined to comment on Rutherford’s retractions. Veenstra-VanderWeele confirmed that he is the new director but did not respond to further questions about the situation.

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In January 2022, the study was temporarily suspended by the U.S. National Institute of Mental Health, following the suicide. It is unknown whether that participant had been taking any antidepressant medication prior to the study.

Four of Rutherford’s published studies were subsequently retracted or corrected for issues related to how participants taking antidepressants at enrollment were handled.

One retraction notice published in February indicates tapering could be challenging and that the researchers did not always stick to the protocol. One-third of the participants taking antidepressants were unable to successfully taper off of them.


Note: The article serves as a cautionary tale about the risks of clinical trials. While clinical trials can be a valuable way to test new drugs and treatments, they also carry risks. Participants in clinical trials may be exposed to experimental drugs that have not been fully tested, and they may experience side effects that are not well-understood.  Ethical researchers must follow guidelines and report accurate results.

Friday, May 17, 2019

Scientific Misconduct in Psychology: A Systematic Review of Prevalence Estimates and New Empirical Data

Johannes Stricker & Armin Günther
Zeitschrift fur Psychologie
Published online: March 29, 2019

Abstract

Spectacular cases of scientific misconduct have contributed to concerns about the validity of published results in psychology. In our systematic review, we identified 16 studies reporting prevalence estimates of scientific misconduct and questionable research practices (QRPs) in psychological research. Estimates from these studies varied due to differences in methods and scope. Unlike other disciplines, there was no reliable lower bound prevalence estimate of scientific misconduct based on identified cases available for psychology. Thus, we conducted an additional empirical investigation on the basis of retractions in the database PsycINFO. Our analyses showed that 0.82 per 10,000 journal articles in psychology were retracted due to scientific misconduct. Between the late 1990s and 2012, there was a steep increase. Articles retracted due to scientific misconduct were identified in 20 out of 22 PsycINFO subfields. These results show that measures aiming to reduce scientific misconduct should be promoted equally across all psychological subfields.

The research is here.


Friday, December 4, 2015

Researchers uncover patterns in how scientists lie about their data

Science Simplified
Originally posted November 16, 2015

Even the best poker players have "tells" that give away when they're bluffing with a weak hand. Scientists who commit fraud have similar, but even more subtle, tells, and a pair of Stanford researchers have cracked the writing patterns of scientists who attempt to pass along falsified data.

The work, published in the Journal of Language and Social Psychology, could eventually help scientists identify falsified research before it is published.

There is a fair amount of research dedicated to understanding the ways liars lie. Studies have shown that liars generally tend to express more negative emotion terms and use fewer first-person pronouns. Fraudulent financial reports typically display higher levels of linguistic obfuscation – phrasing that is meant to distract from or conceal the fake data – than accurate reports.

The entire research review is here.

Tuesday, January 13, 2015

The retraction war

By Jill Neimark
Aeon Magazine
Originally published December 23, 2014

Here is an excerpt:

Retraction was meant to be a corrective for any mistakes or occasional misconduct in science but it has, at times,  taken on a superhero persona instead. Like Superman, retraction can be too powerful, wiping out whole careers with a single blow. Yet it is also like Clark Kent, so mild it can be ignored while fraudsters continue publishing and receiving grants. The process is so wrought that just 5 per cent of scientific misconduct ever results in retraction, leaving an abundance of error in play to obfuscate the facts.

Scientists are increasingly aware of the amount of bad science out there – the word ‘reproducibility’ has become a kind of rallying cry for those who would reform science today. How can we ensure that studies are sound and can be reproduced by other scientists in separate labs?

The entire article is here.

Thursday, August 21, 2014

Scandal claims Japanese scientist's life

Coauthor of retracted stem cell research papers commits suicide, despite being cleared of research misconduct.

Aljazeera News
Originally posted August 5, 2014

A senior Japanese scientist embroiled in a stem-cell research scandal has apparently committed suicide, according to police.

Yoshiki Sasai had supervised and coauthored stem cell research papers that had to be retracted due to falsified contents.

The entire article is here.

Wednesday, July 30, 2014

Corruption of Peer Review Is Harming Scientific Credibility

By Hank Campbell
The Wall Street Journal
Originally published July 13, 2013

Academic publishing was rocked by the news on July 8 that a company called Sage Publications is retracting 60 papers from its Journal of Vibration and Control, about the science of acoustics. The company said a researcher in Taiwan and others had exploited peer review so that certain papers were sure to get a positive review for placement in the journal. In one case, a paper's author gave glowing reviews to his own work using phony names.

Acoustics is an important field. But in biomedicine faulty research and a dubious peer-review process can have life-or-death consequences. In June, Dr. Francis Collins, director of the National Institutes of Health and responsible for $30 billion in annual government-funded research, held a meeting to discuss ways to ensure that more published scientific studies and results are accurate.

The entire article is here.

Wednesday, July 23, 2014

Science Journal Pulls 60 Papers in Peer-Review Fraud

By Henry Fountain
The New York Times
Originally published July 10, 2014

A scientific journal has retracted 60 papers linked to a researcher in Taiwan, accusing him of “perverting the peer-review process” by creating fraudulent online accounts to judge the papers favorably and help get them published.

Sage Publications, publisher of The Journal of Vibration and Control, in which the papers appeared over the last four years, said the researcher, Chen-Yuan Chen, had established a “peer-review and citation ring” consisting of fake scientists as well as real ones whose identities he had assumed.

The entire story is here.

Tuesday, January 8, 2013

OSU prof falsified research results, probes find

Elton hit with work restrictions; he must seek retractions from journals

By  Ben Sutherly
The Columbus Dispatch
Originally published December 22, 2012

An Ohio State University pharmacy professor has agreed to request retractions of much of his research after university and government officials found that he falsified data in six journal articles.

As part of an agreement disclosed yesterday, Terry S. Elton said he will avoid contracting or subcontracting with any agency of the federal government for three years, or serving in any advisory capacity to the U.S. Public Health Service for three years. He will request that five of his scientific publications be retracted.

Federal and university investigations found that Elton falsified data from Western blots, a standard laboratory technique used to detect proteins. Some of Elton’s research explored the brain functions of people with Down syndrome.

The entire story is here.

Monday, July 23, 2012

Uncertainty shrouds psychologist's resignation

Lawrence Sanna departed University of Michigan amid questions over his work from ‘data detective’ Uri Simonsohn.

By Ed Yong
Nature
Originally published July 12, 2012

Uri Simonsohn, the researcher who flagged up questionable data in studies by social psychologist Dirk Smeesters, has revealed the name of a second social psychologist whose data he believes to be suspiciously perfect.

That researcher is Lawrence Sanna, whose former employer, the University of Michigan in Ann Arbor, tells Simonsohn that he resigned his professorship there at the end of May. The reasons for Sanna's resignation are not known, but it followed questions from Simonsohn and a review by Sanna’s previous institution, the University of North Carolina in Chapel Hill (UNC). According to the editor of the Journal of Experimental Social Psychology, Sanna has also asked that three of his papers be retracted from the journal.

In both Smeesters’ and Sanna’s work, odd statistical patterns in the data raised concerns with Simonsohn, at the University of Pennsylvania in Philadelphia. But the similarity between the cases ends there. Smeesters’ resignation was announced on 25 June by his institution, Erasmus University Rotterdam in the Netherlands, which undertook a review and concluded that two of his papers should be retracted. Sanna’s resignation, by contrast, remains mysterious: UNC did not release the results of its review, and the University of Michigan will not explain why Sanna resigned.

The entire story is here.

Wednesday, July 11, 2012

A New Record for Retractions? (Part 2)

By Dennis Normile
ScienceInsider
Originally published on July 2, 2012

An investigating committee in Japan has concluded that a Japanese anesthesiologist, Yoshitaka Fujii, fabricated a whopping 172 papers over the past 19 years. Among other problems, the panel, set up by the Japanese Society of Anesthesiologists, could find no records of patients and no evidence medication was ever administered.

"It is as if someone sat at a desk and wrote a novel about a research idea," the committee wrote in a 29 June summary report posted in Japanese on the society's Web site.

The fabrications could produce a record number of retractions by a single author if the journals, as seems likely, decide to retract the papers. ScienceInsider was unable to reach Fujii, who had asked the society not to provide the media with his contact information.

The entire story is here.

Thursday, April 26, 2012

A Sharp Rise in Retractions Prompts Calls for Reform

By Carl Zimmer
The New York Times
Originally published April 16, 2012

In the fall of 2010, Dr. Ferric C. Fang made an unsettling discovery. Dr. Fang, who is editor in chief of the journal Infection and Immunity, found that one of his authors had doctored several papers.

It was a new experience for him. “Prior to that time,” he said in an interview, “Infection and Immunity had only retracted nine articles over a 40-year period.”

The journal wound up retracting six of the papers from the author, Naoki Mori of the University of the Ryukyus in Japan. And it soon became clear that Infection and Immunity was hardly the only victim of Dr. Mori’s misconduct. Since then, other scientific journals have retracted two dozen of his papers, according to the watchdog blog Retraction Watch.

Wednesday, August 24, 2011

Retractions Of Scientific Studies Are Surging

By Ed Silverman
http://www.pharmalot.com/

Over the past decade, the number of medical journals that have issued retractions has climbed precipitously. Since 2001, the overall number of papers that were published in research journals increased 44 percent, but at the same time, the number of papers that were retracted climbed more than 15-fold, according to The Wall Street Journal, citing data from Thomson Reuters.

Put another way, there were just 22 retraction notices that appeared in journals 10 years ago, but 139 were published in 2006 and by last year, the number reached 339. Through July of this year, there were a total 210 retractions, according to Thomson Reuters Web of Science, which maintains an index of 11,600 peer-reviewed journals.

Meanwhile, retractions related to fraud rose more than sevenfold between 2004 and 2009, exceeding a twofold rise traced to mistakes, according to an analysis published in the Journal of Medical Ethics. After studying 742 papers that were withdrawn from 2000 to 2010, the analysis found that 73.5 percent were retracted simply for error, but 26.6 percent were retracted for fraud. Ominously, 31.8 percent of retracted papers were not noted as retracted (read the abstract).

The conclusion? Either there is more fraud or more policing? Ivan Oransky, the executive editor of Reuters Health and a co-founder of the Retraction Watch blog that began recently in response to the spate of retractions, writes us that the simple use of eyeballs and software that can detect plagiarism has made it possible to root out bad papers.

He also notes, however, that there are more journals, which explains why there are more papers, in general, being published. “So the question is whether there have been more retractions per paper published,” Oransky writes, and then points to this chart to note that were, indeed, many more.

“That’s really no surprise, given the increasing numbers of eyeballs on studies, and the introduction of plagiarism detection software. It’s unclear whether the actual amount of misconduct and legitimate error has grown; it may just be that we’re picking up on more of it,” he continues. “What makes it difficult to tell is a problem we often see at Retraction Watch: Opaque and unhelpful retraction notices saying only ‘this study was withdrawn by the authors.’ How does that make for transparent science? We think journals can do a lot better, by demanding that authors and institutions come clean about what went wrong.”

And why is there more fraud? As the Wall Street Journal notes, there is a lot to be gained - by both researchers and journal editors - to publish influential papers. “The stakes are so high,” The Lancet editor Richard Horton tells the Journal. “A single paper in Lancet and you get your chair and you get your money. It’s your passport to success.”

The entire story can be read here.