Eric Forman
Statnews.com
Originally posted July 24, 2018
Here is an excerpt:
The goal of this process is to achieve a healthy child, which now occurs at a remarkably high rate. For specific genetic disorders, preimplantation genetic testing can reduce the odds of having a child with a lethal disorder from 25 to 50 percent to less than 1 percent.
Medicine’s ability to culture embryos and select healthy ones has improved dramatically in the last few years. A clinical trial that I led several years ago showed that transferring a single genetically tested normal embryo resulted in the same delivery rate as transferring multiple untested embryos. When genetic testing is performed, it is now standard of care to transfer just a single embryo at a time — gone are the days of risky triplet and high-order multiples after IVF. Actual babies, not embryos, are being spared from dying from the complications of genetic diseases and severe prematurity thanks to the increased use of single-embryo transfer afforded by preimplantation genetic testing.
The information is here.
Showing posts with label In Vitro. Show all posts
Showing posts with label In Vitro. Show all posts
Wednesday, September 5, 2018
Tuesday, August 21, 2018
Double time limit for embryo research, say ethics experts
Science News
August 7, 2018
Currently, research on embryos is limited in many countries to a maximum period of 14 days after their fertilisation in the lab.
But ethicists Dr John Appleby of Lancaster University with Professor Dr Annelien Bredenoord of University Medical Center Utrecht believe the current limit is "no longer adequate for current scientific developments."
Dr Appleby and Professor Dr Bredenoord said: "The 14 day rule has been a very successful example of international science regulation, but it should not become a dogma in itself and it should be revisited when no longer fit to purpose."
Until recently, scientists have not been able to culture and sustain embryos in vitro as long as (or beyond) 14 days but this has now changed.
"There are both scientific and ethical reasons to extent the 14 day rule to for example 28 days. Extending the window for embryo research to 28 days would allow scientists to reveal a new in-depth chapter of knowledge about the developmental processes that take place in embryos."
The info is here.
August 7, 2018
Currently, research on embryos is limited in many countries to a maximum period of 14 days after their fertilisation in the lab.
But ethicists Dr John Appleby of Lancaster University with Professor Dr Annelien Bredenoord of University Medical Center Utrecht believe the current limit is "no longer adequate for current scientific developments."
Dr Appleby and Professor Dr Bredenoord said: "The 14 day rule has been a very successful example of international science regulation, but it should not become a dogma in itself and it should be revisited when no longer fit to purpose."
Until recently, scientists have not been able to culture and sustain embryos in vitro as long as (or beyond) 14 days but this has now changed.
"There are both scientific and ethical reasons to extent the 14 day rule to for example 28 days. Extending the window for embryo research to 28 days would allow scientists to reveal a new in-depth chapter of knowledge about the developmental processes that take place in embryos."
The info is here.
Thursday, February 18, 2016
Genetic editing is like playing God – and what’s wrong with that?
Johnjoe McFadden
The Guardian
Originally published February 2, 2016
The announcement that scientists are to be allowed to edit the DNA of human embryos will no doubt provoke an avalanche of warnings from opponents of genetic modification (GM) technology, who will warn that we are “playing God” with our genes.
The opponents are right. We are indeed playing God with our genes. But it is a good thing because God, nature or whatever we want to call the agencies that have made us, often get it wrong and it’s up to us to correct those mistakes.
Sadly, of the half a million or so babies that will be born in the UK this year, about 4% will carry a genetic or major birth defect that could result in an early death, or a debilitating disease that will cause misery for the child and their family. This research will eventually lead to technologies that could edit DNA in the same way that we can edit text – to correct the mistakes before the child’s development goes to its final draft. Its successful implementation could reduce, and eventually eliminate, the birth of babies with severe genetic diseases.
The article is here.
The Guardian
Originally published February 2, 2016
The announcement that scientists are to be allowed to edit the DNA of human embryos will no doubt provoke an avalanche of warnings from opponents of genetic modification (GM) technology, who will warn that we are “playing God” with our genes.
The opponents are right. We are indeed playing God with our genes. But it is a good thing because God, nature or whatever we want to call the agencies that have made us, often get it wrong and it’s up to us to correct those mistakes.
Sadly, of the half a million or so babies that will be born in the UK this year, about 4% will carry a genetic or major birth defect that could result in an early death, or a debilitating disease that will cause misery for the child and their family. This research will eventually lead to technologies that could edit DNA in the same way that we can edit text – to correct the mistakes before the child’s development goes to its final draft. Its successful implementation could reduce, and eventually eliminate, the birth of babies with severe genetic diseases.
The article is here.
Scientists get 'gene editing' go-ahead
By James Gallagher
Health editor, BBC News website
Originally published February 1, 2016
UK scientists have been given the go-ahead by the fertility regulator to genetically modify human embryos.
The research will take place at the Francis Crick Institute in London and aims to provide a deeper understanding of the earliest moments of human life.
The experiments will take place in the first seven days after fertilisation and could explain what goes wrong in miscarriage.
It will be illegal for the scientists to implant the embryos into a woman.
Gene editing is the manipulation of our DNA - the blueprint of life.
In a world-first last year, scientists in China announced that they had carried out gene editing in human embryos to correct a gene that causes a blood disorder.
The field is attracting controversy, with some saying that altering the DNA of an embryo is a step too far and opens the door to designer babies.
The entire article is here.
Health editor, BBC News website
Originally published February 1, 2016
UK scientists have been given the go-ahead by the fertility regulator to genetically modify human embryos.
The research will take place at the Francis Crick Institute in London and aims to provide a deeper understanding of the earliest moments of human life.
The experiments will take place in the first seven days after fertilisation and could explain what goes wrong in miscarriage.
It will be illegal for the scientists to implant the embryos into a woman.
Gene editing is the manipulation of our DNA - the blueprint of life.
In a world-first last year, scientists in China announced that they had carried out gene editing in human embryos to correct a gene that causes a blood disorder.
The field is attracting controversy, with some saying that altering the DNA of an embryo is a step too far and opens the door to designer babies.
The entire article is here.
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