Melissa Davey
The Guardian
Originally published February 5, 2019
A world-first study has called for the mass retraction of more than 400 scientific papers on organ transplantation, amid fears the organs were obtained unethically from Chinese prisoners.
The Australian-led study exposes a mass failure of English language medical journals to comply with international ethical standards in place to ensure organ donors provide consent for transplantation.
The study was published on Wednesday in the medical journal BMJ Open. Its author, the professor of clinical ethics Wendy Rogers, said journals, researchers and clinicians who used the research were complicit in “barbaric” methods of organ procurement.
“There’s no real pressure from research leaders on China to be more transparent,” Rogers, from Macquarie University in Sydney, said. “Everyone seems to say, ‘It’s not our job’. The world’s silence on this barbaric issue must stop.”
A report published in 2016 found a large discrepancy between official transplant figures from the Chinese government and the number of transplants reported by hospitals. While the government says 10,000 transplants occur each year, hospital data shows between 60,000 to 100,000 organs are transplanted each year. The report provides evidence that this gap is being made up by executed prisoners of conscience.
The info is here.
Showing posts with label Experiment. Show all posts
Showing posts with label Experiment. Show all posts
Tuesday, March 5, 2019
Friday, July 3, 2015
The rise of cognitive enhancers is a mass social experiment
By Emma A. Jane and Nicole A. Vincent
The Conversation
Originally posted June 15, 2015
Want to sign up for a massive human experiment? Too late. You’re already a lab rat. There was no ethics approval or informed consent. You weren’t asked, you never signed up, and now there’s no easy way to opt out.
We don’t want to be alarmist. We’re not suggesting you’re about to sprout wings, grow coarse hairs in surprising places and become a gruesome half-insect like the Brundlefly (the side effects of real life scientific experiments rarely impress like the special effects in David Cronenberg’s film The Fly).
But we do know not everyone wants to be a human lab rat. And yet we are all currently enrolled in a massive experiment involving cognitive enhancers.
(cut)
But what drugs, what devices? Well, take this guy, for instance, pumping electricity through his brain with a homegrown transcranial direct current stimulation (tDCS) device that emits a current so small it can run off a nine-volt battery. Or Elizabeth, the 20-something founder of a start-up who takes Adderall – a medication prescribed to treat attention deficit and hyperactivity disorder (ADHD) – except she doesn’t have ADHD.
The entire article is here.
The Conversation
Originally posted June 15, 2015
Want to sign up for a massive human experiment? Too late. You’re already a lab rat. There was no ethics approval or informed consent. You weren’t asked, you never signed up, and now there’s no easy way to opt out.
We don’t want to be alarmist. We’re not suggesting you’re about to sprout wings, grow coarse hairs in surprising places and become a gruesome half-insect like the Brundlefly (the side effects of real life scientific experiments rarely impress like the special effects in David Cronenberg’s film The Fly).
But we do know not everyone wants to be a human lab rat. And yet we are all currently enrolled in a massive experiment involving cognitive enhancers.
(cut)
But what drugs, what devices? Well, take this guy, for instance, pumping electricity through his brain with a homegrown transcranial direct current stimulation (tDCS) device that emits a current so small it can run off a nine-volt battery. Or Elizabeth, the 20-something founder of a start-up who takes Adderall – a medication prescribed to treat attention deficit and hyperactivity disorder (ADHD) – except she doesn’t have ADHD.
The entire article is here.
Tuesday, February 17, 2015
The ethics of deep brain stimulation
Unterrainer M, Oduncu FS
Medicine, Health Care, and Philosophy [2015]
Abstract
Deep brain stimulation (DBS) is an invasive technique designed to stimulate certain deep brain regions for therapeutic purposes and is currently used mainly in patients with neurodegenerative disorders, such as Parkinson's disease. However, DBS is also used increasingly for other experimental applications, such as the treatment of psychiatric disorders (e.g. severe depression), weight reduction. Apart from its therapeutic potential, DBS can cause severe adverse effects, some that might also have a significant impact on the patient's personality and autonomy by the external stimulation of DBS which effects lie beyond the individual's control and free will. The article's purpose is to outline the procedures of DBS currently used in therapeutic and experimental applications and to discuss the ethical concerns regarding this procedure. It will address the clinical benefit-risk-ratio, the particular ethics of research in this field, and the ethical issues raised by affecting a patient's or an individual's personality and autonomous behaviour. Moreover, a potential ethical guideline, the Ulysses contract is discussed for the field of clinical application as well as the question of responsibility.
The entire article is here.
Medicine, Health Care, and Philosophy [2015]
Abstract
Deep brain stimulation (DBS) is an invasive technique designed to stimulate certain deep brain regions for therapeutic purposes and is currently used mainly in patients with neurodegenerative disorders, such as Parkinson's disease. However, DBS is also used increasingly for other experimental applications, such as the treatment of psychiatric disorders (e.g. severe depression), weight reduction. Apart from its therapeutic potential, DBS can cause severe adverse effects, some that might also have a significant impact on the patient's personality and autonomy by the external stimulation of DBS which effects lie beyond the individual's control and free will. The article's purpose is to outline the procedures of DBS currently used in therapeutic and experimental applications and to discuss the ethical concerns regarding this procedure. It will address the clinical benefit-risk-ratio, the particular ethics of research in this field, and the ethical issues raised by affecting a patient's or an individual's personality and autonomous behaviour. Moreover, a potential ethical guideline, the Ulysses contract is discussed for the field of clinical application as well as the question of responsibility.
The entire article is here.
Monday, August 18, 2014
When Cupid fires arrows double-blind: implicit informed agreement for online research?
By Anders Sandberg
Practical Ethics
Originally posted on Jul 31, 2014
A while ago Facebook got into the news for experimenting on its subscribers, leading to a fair bit of grumbling. Now the dating site OKCupid has proudly outed itself: We Experiment On Human Beings! Unethical or not?
(cut)
The harm angle is more interesting. While Facebook affected the emotions slightly on people who might not have expected emotional manipulation, OKCupid is all about emotions and emotion-laden social interaction. People date because of the site. People have sex because of the site. People marry because of the site. Potentially manipulations could have far more far reaching consequences on OKCupid than on Facebook.
The entire blog post is here.
Practical Ethics
Originally posted on Jul 31, 2014
A while ago Facebook got into the news for experimenting on its subscribers, leading to a fair bit of grumbling. Now the dating site OKCupid has proudly outed itself: We Experiment On Human Beings! Unethical or not?
(cut)
The harm angle is more interesting. While Facebook affected the emotions slightly on people who might not have expected emotional manipulation, OKCupid is all about emotions and emotion-laden social interaction. People date because of the site. People have sex because of the site. People marry because of the site. Potentially manipulations could have far more far reaching consequences on OKCupid than on Facebook.
The entire blog post is here.
Thursday, May 15, 2014
The Reformation: Can Social Scientists Save Themselves?
By Jerry Adler
Pacific Standard: The Science of Society
Originally posted April 28, 2014
Here is two excerpts to a long, yet exceptional, article on research in the social sciences:
OUTRIGHT FAKERY IS CLEARLY more common in psychology and other sciences than we’d like to believe. But it may not be the biggest threat to their credibility. As the journalist Michael Kinsley once said of wrongdoing in Washington, so too in the lab: “The scandal is what’s legal.” The kind of manipulation that went into the “When I’m Sixty-Four” paper, for instance, is “nearly universally common,” Simonsohn says. It is called “p-hacking,” or, more colorfully, “torturing the data until it confesses.”
P is a central concept in statistics: It’s the mathematical factor that mediates between what happens in the laboratory and what happens in the real world. The most common form of statistical analysis proceeds by a kind of backwards logic: Technically, the researcher is trying to disprove the “null hypothesis,” the assumption that the condition under investigation actually makes no difference.
(cut)
WHILE IT IS POSSIBLE to detect suspicious patterns in scientific data from a distance, the surest way to find out whether a study’s findings are sound is to do the study all over again. The idea that experiments should be replicable, producing the same results when run under the same conditions, was identified as a defining feature of science by Roger Bacon back in the 13th century. But the replication of previously published results has rarely been a high priority for scientists, who tend to regard it as grunt work. Journal editors yawn at replications. Honors and advancement in science go to those who publish new, startling results, not to those who confirm—or disconfirm—old ones.
The entire article is here.
Pacific Standard: The Science of Society
Originally posted April 28, 2014
Here is two excerpts to a long, yet exceptional, article on research in the social sciences:
OUTRIGHT FAKERY IS CLEARLY more common in psychology and other sciences than we’d like to believe. But it may not be the biggest threat to their credibility. As the journalist Michael Kinsley once said of wrongdoing in Washington, so too in the lab: “The scandal is what’s legal.” The kind of manipulation that went into the “When I’m Sixty-Four” paper, for instance, is “nearly universally common,” Simonsohn says. It is called “p-hacking,” or, more colorfully, “torturing the data until it confesses.”
P is a central concept in statistics: It’s the mathematical factor that mediates between what happens in the laboratory and what happens in the real world. The most common form of statistical analysis proceeds by a kind of backwards logic: Technically, the researcher is trying to disprove the “null hypothesis,” the assumption that the condition under investigation actually makes no difference.
(cut)
WHILE IT IS POSSIBLE to detect suspicious patterns in scientific data from a distance, the surest way to find out whether a study’s findings are sound is to do the study all over again. The idea that experiments should be replicable, producing the same results when run under the same conditions, was identified as a defining feature of science by Roger Bacon back in the 13th century. But the replication of previously published results has rarely been a high priority for scientists, who tend to regard it as grunt work. Journal editors yawn at replications. Honors and advancement in science go to those who publish new, startling results, not to those who confirm—or disconfirm—old ones.
The entire article is here.
Sunday, March 2, 2014
Scientific method: Statistical errors
P values, the 'gold standard' of statistical validity, are not as reliable as many scientists assume.
By Regina Nuzzo
Nature
Originally published February 12, 2014
For a brief moment in 2010, Matt Motyl was on the brink of scientific glory: he had discovered that extremists quite literally see the world in black and white.
The results were “plain as day”, recalls Motyl, a psychology PhD student at the University of Virginia in Charlottesville. Data from a study of nearly 2,000 people seemed to show that political moderates saw shades of grey more accurately than did either left-wing or right-wing extremists. “The hypothesis was sexy,” he says, “and the data provided clear support.” The P value, a common index for the strength of evidence, was 0.01 — usually interpreted as 'very significant'. Publication in a high-impact journal seemed within Motyl's grasp.
But then reality intervened. Sensitive to controversies over reproducibility, Motyl and his adviser, Brian Nosek, decided to replicate the study. With extra data, the P value came out as 0.59 — not even close to the conventional level of significance, 0.05. The effect had disappeared, and with it, Motyl's dreams of youthful fame.
The entire article is here.
By Regina Nuzzo
Nature
Originally published February 12, 2014
For a brief moment in 2010, Matt Motyl was on the brink of scientific glory: he had discovered that extremists quite literally see the world in black and white.
The results were “plain as day”, recalls Motyl, a psychology PhD student at the University of Virginia in Charlottesville. Data from a study of nearly 2,000 people seemed to show that political moderates saw shades of grey more accurately than did either left-wing or right-wing extremists. “The hypothesis was sexy,” he says, “and the data provided clear support.” The P value, a common index for the strength of evidence, was 0.01 — usually interpreted as 'very significant'. Publication in a high-impact journal seemed within Motyl's grasp.
But then reality intervened. Sensitive to controversies over reproducibility, Motyl and his adviser, Brian Nosek, decided to replicate the study. With extra data, the P value came out as 0.59 — not even close to the conventional level of significance, 0.05. The effect had disappeared, and with it, Motyl's dreams of youthful fame.
The entire article is here.
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