What is a moral epigenetic responsibility?

Charles Dupras & Vardit Ravitsky
BMJ Blog
Originally posted August 23, 2016

Epigenetics is a recent yet promising field of scientific research. It explores the influence of the biochemical environment (food, toxic pollutants) and the social environment (stress, child abuse, socio-economic status) on the expression of genes, i.e. on whether and how they will switch ‘on’ or ‘off’. Epigenetic modifications can have a significant impact on health and disease later in life. Most surprisingly, it was suggested that some epigenetic variants (or ‘epi-mutations’) acquired during one’s life could be transmitted to offspring, thus having long-term effects on the health of future generations.

Epigenetics is increasingly capturing the attention of social scientists and ethicists, because it brings attention to the importance of environmental exposure for the developing foetus and child as a risk factor for common diseases such as cardiovascular, diabetes, obesity, allergies and cancers. Scholars such as Hannah Landecker, Mark Rothstein and Maurizio Meloni have argued that epigenetics may be used to promote various arguments in ongoing debates on environmental and social justice, as well as intergenerational equity. Some even suggested that epigenetics could lead to novel ways of thinking about moral responsibilities for health.

The blog post is here.

Epigenetics in the neoliberal 'regime of truth'

by Charles Dupras and Vardit Ravitsky
Hastings Center Report - 2015

Here is an excerpt:

In this paper, we argue that the impetus to create new biomedical interventions to manipulate and reverse epigenetic variants is likely to garner more attention than effective social and public health interventions and therefore also to garner a greater share of limited public resources. This is likely to happen, we argue, because of the current biopolitical context in  which scientific findings are translated. This contemporary neoliberal “regime of truth,” to use a term from the historian and philosopher Michel Foucault, greatly influences the ways in which knowledge is being interpreted and implemented. Building on sociologist Thomas Lemke’s Foucauldian “analytics of biopolitics” and on literature from the field of science and technology studies,  we present two sociological trends that may impede the policy transla-tion of epigenetics: molecularization and biomedicalization. These trends,  we argue, are likely to favor the clini-cal translation of epigenetics—in other words, the development of new clinical tools fostering what has been called “personalized” or “precision” medicine.

In addition, we argue that an over-emphasized clinical translation of epigenetics may further reinforce this biopolitical landscape through four processes that are closely related to neoliberal pathways of thinking: the internalization and isolation (liberal individualism) of socioenvironmental determinants of health and increased opportunities for commodification and technologicalization  (economic liberalism) of health care interventions. Hence, epigenetics may end up promoting further the mobilization of resources toward technological innovation at the expense of public health and social strategies. Our analysis therefore first presents how the current biopolitical landscape may bias scientific knowledge translation and then circles around to explain how, in return, the outcome of a biased translation of epigenetics may strengthen our contemporary neoliberal “regime of truth.”

The paper is here.

Born this way? How high-tech conversion therapy could undermine gay rights

By Andrew Vierra and Brian Earp
The Conversation
Originally published on April 21, 2015

Here is an excerpt:

We fully agree with the President and believe that this is a step in the right direction. Of course, in addition to being unsafe as well as ethically unsound, current conversion therapy approaches aren’t actually effective at doing what they claim to do – changing sexual orientation.

But we also worry that this may be a short-term legislative solution to what is really a conceptual problem.

The question we ought to be asking is “what will happen if and when scientists do end up developing safe and effective technologies that can alter sexual orientation?”

Based on current scientific research, it is not unlikely that medical researchers – in the not-too-distant future – will know enough about the genetic, epigenetic, neurochemical and other brain-level factors that are involved in shaping sexual orientation that these variables could in fact be successfully modified.

The entire article is here.

In Genes We Trust: How Our Essentialist Biases Distort How We Think About Genes

Posted by Peter B. Reiner
Neuroethics at the Core
Posted March 7, 2014

This video was recorded on October 23-25, 2013 during a Peter Wall Institute for Advanced Studies International Roundtable, "We Are Our Brains", led by Principal Investigator Dr. Peter B. Reiner (Department of Psychiatry, UBC and the National Core for Neuroethics).

To learn more about We Are Our Brains.

What to Consider Before Undergoing a DNA Test

By Anne Tergesen
The Wall Street Journal
Originally published December 8, 2013

As the price of sequencing a person's entire DNA has tumbled from $1 billion a decade ago to a few thousand dollars today, many adults—and their physicians—are turning to genetic tests to better understand and manage their health.

The process, though, can be problematic. Some people who test, like the actress Angelina Jolie, learn information that can have dramatic consequences for their health and insurability—and that of their relatives.

And the testing business itself is still young and experiencing growing pains. Last month the Food and Drug Administration ordered genetic-testing firm 23andMe Inc. to stop marketing its $99 mail-order kit. The agency warned that false results could prompt consumers to undergo unnecessary health procedures. The company halted all ads for the kit and said it would work with regulators to address their concerns.

The entire article is here.

Epigenetics: How to alter your genes

We’ve long been told our genes are our destiny. But it’s now thought they can be changed by habit, lifestyle, even finances. What does this mean for our children?

By Chris Bell
The Telegraph
Originally published on October 16, 2013

Here is an excerpt:

And yet a quiet scientific revolution is changing that thinking. For it seems you might also be what your mother ate. How much your father drank. And what your grandma smoked. Likewise your own children, too, may be shaped by whether you spend your evenings jogging, worrying about work, or sat on the sofa eating Wotsits. And that nurture, rather than our intractable nature, may determine who we are far more than was ever previously thought.

Epigenetics is a relatively new scientific field; research only began in earnest in the mid Nineties, and has only found traction in the wider scientific community in the last decade or so. And the sources of its data are eclectic, to say the least – stretching from famines in northern Sweden to the 9/11 attacks to the medical notes of Audrey Hepburn.

The entire story is here.

Proposed Treatment To Fix Genetic Diseases Raising Ethics Issues

by ROB STEIN
NPR News
Originally published October 09, 2013

Here is an excerpt:

Specifically, the research would create an egg with healthy mitochondrial DNA (mtDNA). Unlike the DNA that most people are familiar with — the 23 pairs of human chromosomes that program most of our body processes — mtDNA is the bit of genetic material inside mitochondria, living structures inside a cell that provide its energy.

Scientists estimate that one in every 200 women carries defects in her mtDNA. Between one in 2,000 and one in 4,000 babies may be born each year with syndromes caused by these genetic glitches; the syndromes range from mild to severe. In many cases, there is no treatment and the affected child dies early in life.

The entire story is here.

Ethics: Taboo genetics

By Ericka Check Hayden
Nature.com
Originally published October 2, 2013

Here is an excerpt:

At the root of this caution is the widespread but antiquated idea that genetics is destiny — that someone's genes can accurately predict complex behaviours and traits regardless of their environment. The public and many scientists have continued to misinterpret modern findings on the basis of this — fearing that the work will lead to a new age of eugenics, preemptive imprisonment and discrimination against already marginalized groups.

“People can take science and assume it is far more determinative than it is — and, by making that assumption, make choices that we will come to regret as a society,” says Nita Farahany, a philosopher and lawyer at Duke University School of Law in Durham, North Carolina.

But trying to forestall such poor choices by drawing red lines around certain areas subverts science, says Christopher Chabris of Union College in Schenectady, New York. Funding for research in some areas dries up and researchers are dissuaded from entering promising fields. “Any time there's a taboo or norm against studying something for anything other than good scientific reasons, it distorts researchers' priorities and can harm the understanding of related topics,” he says.

The entire story is here.

Why do identical twins end up having such different lives?

Their genes are exactly the same, so why don't identical siblings' lives follow more similar patterns? The scientist behind a pioneering 21-year study believes he has the answer

By Robin McKie
The Guardian/The Observer
Originally published June 1, 2013

Here is one excerpt:

"We now began to look not at the similarities between identical twins but the differences. It was a shift in perception really. Our work shows that the heritability of your age at death is only about 25%. Similarly, there is only a 30% chance that if one identical twin gets heart disease the other one will as well, while the figure for rheumatoid arthritis is only about 15%."

It is a baffling observation: individuals with identical genes and often very similar conditions of upbringing but who experience very different life outcomes. What could be the cause? The answer, says Spector, came to him in a Damascene moment four years ago. The causes of these differences were due to changes in the human epigenome, he realised.

"Essentially, epigenetics is the mechanism by which environmental changes alter the behaviour of our genes," he says. "This involves a process known as methylation, which occurs when a chemical known as methyl, which floats around the inside of our cells, attaches itself to our DNA. When it does so, it can inhibit or turn down the activity of a gene and block it from making a particular version of a protein in our bodies." Crucially, all sorts of life events can affect DNA methylation levels in our bodies: diet, illnesses, ageing, chemicals in the environment, smoking, drugs and medicines.

Thus epigenetic changes produce variation in disease patterns. And recent experiments carried out by Spector and his colleagues, in which they have looked at methylation levels in pairs of identical twins, back the theory. "We have studied identical twins who have different tolerances to pain and shown that they have different states of methylation. We have also produced similar results for depression, diabetes and breast cancer. In each case, we have found genes that are switched on in one twin and switched off in the other twin. This often determines whether or not they are likely to get a disease."

Epigenetic changes are not just simple environmental changes, however. They influence a person's genes and can have an effect that can last for two or three generations in extreme cases. For example, studies of the children and grandchildren of pregnant women who endured starvation in the second world war and in China in the 50s have revealed they tended to be smaller and more prone to diabetes and psychosis. These trends are put down to epigenetic changes.

The entire article is here.

Thanks to Ed Zuckerman for this article.  The article may change the way that a psychologist thinks about twin study research indicating biological bases of psychopathology.