Welcome to the Nexus of Ethics, Psychology, Morality, Philosophy and Health Care

Welcome to the nexus of ethics, psychology, morality, technology, health care, and philosophy
Showing posts with label Brain Stimulation. Show all posts
Showing posts with label Brain Stimulation. Show all posts

Monday, May 10, 2021

Do Brain Implants Change Your Identity?

Christine Kenneally
The New Yorker
Originally posted 19 Apr 21

Here are two excerpts:

Today, at least two hundred thousand people worldwide, suffering from a wide range of conditions, live with a neural implant of some kind. In recent years, Mark Zuckerberg, Elon Musk, and Bryan Johnson, the founder of the payment-processing company Braintree, all announced neurotechnology projects for restoring or even enhancing human abilities. As we enter this new era of extra-human intelligence, it’s becoming apparent that many people develop an intense relationship with their device, often with profound effects on their sense of identity. These effects, though still little studied, are emerging as crucial to a treatment’s success.

The human brain is a small electrical device of super-galactic complexity. It contains an estimated hundred billion neurons, with many more links between them than there are stars in the Milky Way. Each neuron works by passing an electrical charge along its length, causing neurotransmitters to leap to the next neuron, which ignites in turn, usually in concert with many thousands of others. Somehow, human intelligence emerges from this constant, thrilling choreography. How it happens remains an almost total mystery, but it has become clear that neural technologies will be able to synch with the brain only if they learn the steps of this dance.

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For the great majority of patients, deep-brain stimulation was beneficial and life-changing, but there were occasional reports of strange behavioral reactions, such as hypomania and hypersexuality. Then, in 2006, a French team published a study about the unexpected consequences of otherwise successful implantations. Two years after a brain implant, sixty-five per cent of patients had a breakdown in their marriages or relationships, and sixty-four per cent wanted to leave their careers. Their intellect and their levels of anxiety and depression were the same as before, or, in the case of anxiety, had even improved, but they seemed to experience a fundamental estrangement from themselves. One felt like an electronic doll. Another said he felt like RoboCop, under remote control.

Gilbert describes himself as “an applied eliminativist.” He doesn’t believe in a soul, or a mind, at least as we normally think of them, and he strongly questions whether there is a thing you could call a self. He suspected that people whose marriages broke down had built their identities and their relationships around their pathologies. When those were removed, the relationships no longer worked. Gilbert began to interview patients. He used standardized questionnaires, a procedure that is methodologically vital for making dependable comparisons, but soon he came to feel that something about this unprecedented human experience was lost when individual stories were left out. The effects he was studying were inextricable from his subjects’ identities, even though those identities changed.

Many people reported that the person they were after treatment was entirely different from the one they’d been when they had only dreamed of relief from their symptoms. Some experienced an uncharacteristic buoyancy and confidence. One woman felt fifteen years younger and tried to lift a pool table, rupturing a disk in her back. One man noticed that his newfound confidence was making life hard for his wife; he was too “full-on.” Another woman became impulsive, walking ten kilometres to a psychologist’s appointment nine days after her surgery. She was unrecognizable to her family. They told her that they grieved for the old her.

Sunday, March 4, 2018

Increasing honesty in humans with noninvasive brain stimulation

Michel André Maréchal, Alain Cohn, Giuseppe Ugazio and Christian C. Ruff
Proceedings of the National Academy of Sciences (PNAS)
April, 114(17), 4360-4364

Abstract

Honesty plays a key role in social and economic interactions and is crucial for societal functioning. However, breaches of honesty are pervasive and cause significant societal and economic problems that can affect entire nations. Despite its importance, remarkably little is known about the neurobiological mechanisms supporting honest behavior. We demonstrate that honesty can be increased in humans with transcranial direct current stimulation (tDCS) over the right dorsolateral prefrontal cortex. Participants (n = 145) completed a die-rolling task where they could misreport their outcomes to increase their earnings, thereby pitting honest behavior against personal financial gain. Cheating was substantial in a control condition but decreased dramatically when neural excitability was enhanced with tDCS. This increase in honesty could not be explained by changes in material self-interest or moral beliefs and was dissociated from participants’ impulsivity, willingness to take risks, and mood. A follow-up experiment (n = 156) showed that tDCS only reduced cheating when dishonest behavior benefited the participants themselves rather than another person, suggesting that the stimulated neural process specifically resolves conflicts between honesty and material self-interest. Our results demonstrate that honesty can be strengthened by noninvasive interventions and concur with theories proposing that the human brain has evolved mechanisms dedicated to control complex social behaviors.

The article is here.

Sunday, March 26, 2017

Moral Enhancement Using Non-invasive Brain Stimulation

R. Ryan Darby and Alvaro Pascual-Leone
Front. Hum. Neurosci., 22 February 2017
https://doi.org/10.3389/fnhum.2017.00077

Biomedical enhancement refers to the use of biomedical interventions to improve capacities beyond normal, rather than to treat deficiencies due to diseases. Enhancement can target physical or cognitive capacities, but also complex human behaviors such as morality. However, the complexity of normal moral behavior makes it unlikely that morality is a single capacity that can be deficient or enhanced. Instead, our central hypothesis will be that moral behavior results from multiple, interacting cognitive-affective networks in the brain. First, we will test this hypothesis by reviewing evidence for modulation of moral behavior using non-invasive brain stimulation. Next, we will discuss how this evidence affects ethical issues related to the use of moral enhancement. We end with the conclusion that while brain stimulation has the potential to alter moral behavior, such alteration is unlikely to improve moral behavior in all situations, and may even lead to less morally desirable behavior in some instances.

The article is here.

Tuesday, November 22, 2016

The real problem (of consciousness)

Anil K Seth
Aeon.com
Originally posted November 2, 2016

Here is an excerpt:

So what underlies being conscious specifically, as opposed to just being awake? We know it’s not just the number of neurons involved. The cerebellum (the so-called ‘little brain’ hanging off the back of the cortex) has about four times as many neurons as the rest of the brain, but seems barely involved in maintaining conscious level. It’s not even the overall level of neural activity – your brain is almost as active during dreamless sleep as it is during conscious wakefulness. Rather, consciousness seems to depend on how different parts of the brain speak to each other, in specific ways.

A series of studies by the neuroscientist Marcello Massimini at the University of Milan provides powerful evidence for this view. In these studies, the brain is stimulated by brief pulses of energy – using a technique called transcranial magnetic stimulation (TMS) – and its electrical ‘echoes’ are recorded using EEG. In dreamless sleep and general anaesthesia, these echoes are very simple, like the waves generated by throwing a stone into still water. But during conscious states, a typical echo ranges widely over the cortical surface, disappearing and reappearing in complex patterns. Excitingly, we can now quantify the complexity of these echoes by working out how compressible they are, similar to how simple algorithms compress digital photos into JPEG files. The ability to do this represents a first step towards a ‘consciousness-meter’ that is both practically useful and theoretically motivated.

The article is here.

Friday, April 15, 2016

Brain stimulation in sport: is it fair?

By Nick Davis
The Conversation
Originally published March 16, 2016

If I tried to sell you a drink or a tablet, claiming it would make you run faster or improve your tennis serve, you would be suspicious. Taking a supplement to boost performance in sport feels like cheating, and it generally is.

However, new advances in neuroscience have pointed the way to performance enhancement by stimulating the activity of the brain. Mild electrical stimulation using electrodes placed on the head – called transcranial direct current stimulation, or tDCS, makes the brain more or less active, and may lead to long-lasting changes in brain processing.

The article is here.

Thursday, February 25, 2016

The practices of do-it-yourself brain stimulation: implications for ethical considerations and regulatory proposals

Anna Wexler
J Med Ethics doi:10.1136/medethics-2015-102704

Abstract

Scientists and neuroethicists have recently drawn attention to the ethical and regulatory issues surrounding the do-it-yourself (DIY) brain stimulation community, which comprises individuals stimulating their own brains with transcranial direct current stimulation (tDCS) for self-improvement. However, to date, existing regulatory proposals and ethical discussions have been put forth without engaging those involved in the DIY tDCS community or attempting to understand the nature of their practices. I argue that to better contend with the growing ethical and safety concerns surrounding DIY tDCS, we need to understand the practices of the community. This study presents the results of a preliminary inquiry into the DIY tDCS community, with a focus on knowledge that is formed, shared and appropriated within it. I show that when making or acquiring a device, DIYers (as some members call themselves) produce a body of knowledge that is completely separate from that of the scientific community, and share it via online forums, blogs, videos and personal communications. However, when applying tDCS, DIYers draw heavily on existing scientific knowledge, posting links to academic journal articles and scientific resources and adopting the standardised electrode placement system used by scientists. Some DIYers co-opt scientific knowledge and modify it by creating their own manuals and guides based on published papers. Finally, I explore how DIYers cope with the methodological limitations inherent in self-experimentation. I conclude by discussing how a deeper understanding of the practices of DIY tDCS has important regulatory and ethical implications.

The article is here.

Friday, July 3, 2015

The rise of cognitive enhancers is a mass social experiment

By Emma A. Jane and Nicole A. Vincent
The Conversation
Originally posted June 15, 2015

Want to sign up for a massive human experiment? Too late. You’re already a lab rat. There was no ethics approval or informed consent. You weren’t asked, you never signed up, and now there’s no easy way to opt out.

We don’t want to be alarmist. We’re not suggesting you’re about to sprout wings, grow coarse hairs in surprising places and become a gruesome half-insect like the Brundlefly (the side effects of real life scientific experiments rarely impress like the special effects in David Cronenberg’s film The Fly).

But we do know not everyone wants to be a human lab rat. And yet we are all currently enrolled in a massive experiment involving cognitive enhancers.

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But what drugs, what devices? Well, take this guy, for instance, pumping electricity through his brain with a homegrown transcranial direct current stimulation (tDCS) device that emits a current so small it can run off a nine-volt battery. Or Elizabeth, the 20-something founder of a start-up who takes Adderall – a medication prescribed to treat attention deficit and hyperactivity disorder (ADHD) – except she doesn’t have ADHD.

The entire article is here.

Tuesday, February 17, 2015

The ethics of deep brain stimulation

Unterrainer M, Oduncu FS
Medicine, Health Care, and Philosophy [2015]

Abstract

Deep brain stimulation (DBS) is an invasive technique designed to stimulate certain deep brain regions for therapeutic purposes and is currently used mainly in patients with neurodegenerative disorders, such as Parkinson's disease. However, DBS is also used increasingly for other experimental applications, such as the treatment of psychiatric disorders (e.g. severe depression), weight reduction. Apart from its therapeutic potential, DBS can cause severe adverse effects, some that might also have a significant impact on the patient's personality and autonomy by the external stimulation of DBS which effects lie beyond the individual's control and free will. The article's purpose is to outline the procedures of DBS currently used in therapeutic and experimental applications and to discuss the ethical concerns regarding this procedure. It will address the clinical benefit-risk-ratio, the particular ethics of research in this field, and the ethical issues raised by affecting a patient's or an individual's personality and autonomous behaviour. Moreover, a potential ethical guideline, the Ulysses contract is discussed for the field of clinical application as well as the question of responsibility.

The entire article is here.

Sunday, November 30, 2014

Brain stimulation for ‘enhancement’ in children: An ethical analysis

By Hannah Maslen, Brian D Earp, Roi Cohen-Kadosh and Julian Savulescu
Frontiers in Human Neuroscience
Revised on November 6, 2014

Abstract

Davis (2014) called for "extreme caution" in the use of non-invasive brain stimulation (NIBS) to treat neurological disorders in children, due to gaps in scientific knowledge. We are sympathetic to his position. However, we must also address the ethical implications of applying this technology to minors. Compensatory trade-offs associated with NIBS present a challenge to its use in children, insofar as these trade-offs have the effect of limiting the child's future options. The distinction between treatment and enhancement has some normative force here. As the intervention moves away from being a treatment toward being an enhancement—and thus toward a more uncertain weighing of the benefits, risks, and costs—considerations of the child’s best interests (as judged by the parents) diminish, and the need to protect the child's (future) autonomy looms larger. NIBS for enhancement involving trade-offs should therefore be delayed, if possible, until the child reaches a state of maturity and can make an informed, personal decision. NIBS for treatment, by contrast, is permissible insofar as it can be shown to be at least as safe and effective as currently approved treatments, which are (themselves) justified on a best interests standard.

The entire article is here.

Wednesday, October 8, 2014

Could Deep-Brain Stimulation Fortify Soldiers’ Minds?

By S. Matthew Liao
Scientific American Blog
Originally posted September 4, 2014

Here is an excerpt:

Brain implants that reduce or eliminate our sense of morality are morally undesirable and are not really enhancements as such. Efforts should therefore be made to ensure that the kind of brain implants we develop do not have these unwanted side effects. In the short term, the brain implants we develop may well be imperfect in just such a way. If so, this would be a good reason to ban such devices in the short term. The interesting theoretical issue is what happens when we have perfected the technology and have brain implants that would enable a soldier to kill at the right time, for the right reasons, and in a proportionate manner? Would we still have ethical problems with soldiers using such a technology

The entire blog post is here.