Welcome to the Nexus of Ethics, Psychology, Morality, Philosophy and Health Care

Welcome to the nexus of ethics, psychology, morality, technology, health care, and philosophy
Showing posts with label Basic Science. Show all posts
Showing posts with label Basic Science. Show all posts

Tuesday, January 13, 2015

The retraction war

By Jill Neimark
Aeon Magazine
Originally published December 23, 2014

Here is an excerpt:

Retraction was meant to be a corrective for any mistakes or occasional misconduct in science but it has, at times,  taken on a superhero persona instead. Like Superman, retraction can be too powerful, wiping out whole careers with a single blow. Yet it is also like Clark Kent, so mild it can be ignored while fraudsters continue publishing and receiving grants. The process is so wrought that just 5 per cent of scientific misconduct ever results in retraction, leaving an abundance of error in play to obfuscate the facts.

Scientists are increasingly aware of the amount of bad science out there – the word ‘reproducibility’ has become a kind of rallying cry for those who would reform science today. How can we ensure that studies are sound and can be reproduced by other scientists in separate labs?

The entire article is here.

Monday, November 10, 2014

U.S Troops and Patients Were Used as Malaria Guinea Pigs

By Bill Briggs
NBC News

Tens of thousands of mental patients and troops unknowingly became malaria test subjects during the 1940s — part of a secret federal rush to cure a dread disease and win a world war, according to a book published Tuesday that exposes vast, previously unknown breaches of medical ethics.

“The Malaria Project” — operating via the same covert White House machinery that drove the Manhattan Project — tasked doctors with removing malaria from naturally exposed U.S. troops then injecting those strains into people with syphilis and schizophrenia, reports author Karen Masterson, who researched files at the National Archives.

Some details of the project have been previously reported, but the book's new revelations renew debate over the ethics of using unsuspecting people as test subjects — similar to the Tuskegee Syphilis Study on low-income black men.

The entire story is here.

Thursday, July 10, 2014

Facebook’s Unethical Experiment

It intentionally manipulated users’ emotions without their knowledge.

By Katy Waldman
Slate
Originally published on June 28, 2014

Facebook has been experimenting on us. A new paper in the Proceedings of the National Academy of Sciences reveals that Facebook intentionally manipulated the news feeds of almost 700,000 users in order to study “emotional contagion through social networks.”

The researchers, who are affiliated with Facebook, Cornell, and the University of California–San Francisco, tested whether reducing the number of positive messages people saw made those people less likely to post positive content themselves. The same went for negative messages: Would scrubbing posts with sad or angry words from someone’s Facebook feed make that person write fewer gloomy updates?

They tweaked the algorithm by which Facebook sweeps posts into members’ news feeds, using a program to analyze whether any given textual snippet contained positive or negative words. Some people were fed primarily neutral to happy information from their friends; others, primarily neutral to sad. Then everyone’s subsequent posts were evaluated for affective meanings.

The entire story is here.

Tuesday, July 8, 2014

Embodied free will beliefs: Some effects of physical states on metaphysical opinions.

Ent, M. R., & Baumeister, R. F. (2014). Embodied free will beliefs: Some effects of physical states on metaphysical opinions. Consciousness and Cognition, 27, 147-154.

Abstract

The present research suggests that people's bodily states affect their beliefs about free will. People with epilepsy and people with panic disorder, which are disorders characterized by a lack of control over one's body, reported less belief in free will compared to people without such disorders (Study 1). The more intensely people felt sexual desire, physical tiredness, and the urge to urinate, the less they believed in free will (Study 2). Among non-dieters, the more intensely they felt hunger, the less they believed in free will. However, dieters showed a trend in the opposite direction (Study 3).

Introduction

A growing body of literature suggests that people’s bodily states and sensations affect how they process information (Niedenthal, Barsalou, Winkielman, Krauth-Gruber, & Ric, 2005). To date, much of the research on this topic has focused on how bodily cues activate specific responses to specific stimuli. For example, many studies have demonstrated that making approach versus avoidance arm movements can affect people’s judgments of a target stimulus (e.g., Cacioppo, Priester, & Berntson, 1993; Glenberg & Kaschak, 2002). Taking that work a bold and meaningful step further, recent work has suggested
that bodily states and sensations may also affect people’s broad, abstract views about the social world. Specifically, having a proclivity toward feeling physically disgusted has been linked to political conservatism (Inbar, Pizarro, & Bloom, 2009; Inbar, Pizarro, Iyer, & Haidt, 2011; Terrizzi, Shook, & Ventis, 2010). In the present research, we tested the hypothesis that bodily states are related to a different type of broad, abstract view: belief in free will.

Belief in free will has important behavioral consequences. People’s aggression, dishonesty, helpfulness, job performance, and conformity have all been found to be related to their beliefs about free will (Alquist & Baumeister, 2010; Baumeister, Masicampo, & DeWall, 2009; Stillman, Baumeister, & Mele, 2011; Vohs & Schooler, 2008). Therefore, the factors that shape people’s free will beliefs may have far-reaching effects. However, research about the factors that affect free will beliefs is scarce.

The entire article here, behind a paywall.

Wednesday, June 25, 2014

Harvard report shines light on ex-researcher’s misconduct

By Carolyn Y. Johson
The Boston Globe
Originally published May 30, 2014

When former Harvard psychology professor Marc Hauser was found solely responsible in a series of six scientific misconduct cases in 2012, he distanced himself from the problems, portraying them as an unfortunate consequence of his heavy workload. He said he took responsibility, “whether or not I was directly involved.”

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The 85-page report details instances in which Hauser changed data so that it would show a desired effect. It shows that he more than once rebuffed or downplayed questions and concerns from people in his laboratory about how a result was obtained. The report also describes “a disturbing pattern of misrepresentation of results and shading of truth” and a “reckless disregard for basic scientific standards.”

The entire article is here.

Wednesday, April 16, 2014

Statistical Flaw Punctuates Brain Research in Elite Journals

By Gary Stix
Scientific American
Originally published March 27, 2014

Here is an excerpt:

That is the message of a new analysis in Nature Neuroscience that shows that more than half of 314 articles on neuroscience in elite journals   during an 18-month period failed to take adequate measures to ensure that statistically significant study results were not, in fact, erroneous. Consequently, at  least some of the results from papers in journals like Nature, Science, Nature Neuroscience and Cell were likely to be false positives, even after going through the arduous peer-review gauntlet.

The entire article is here.

Wednesday, April 9, 2014

Behavioural economics and public policy

By Tim Harford
The Financial Times
Originally published March 17, 2014

Here is an excerpt:

Behavioural economics is one of the hottest ideas in public policy. The UK government’s Behavioural Insights Team (BIT) uses the discipline to craft better policies, and in February was part-privatised with a mission to advise governments around the world. The White House announced its own behavioural insights team last summer.

So popular is the field that behavioural economics is now often misapplied as a catch-all term to refer to almost anything that’s cool in popular social science, from the storycraft of Malcolm Gladwell, author of The Tipping Point (2000), to the empirical investigations of Steven Levitt, co-author of Freakonomics (2005).

Yet, as with any success story, the backlash has begun. Critics argue that the field is overhyped, trivial, unreliable, a smokescreen for bad policy, an intellectual dead-end – or possibly all of the above.

The entire article is here.

Sunday, March 2, 2014

Scientific method: Statistical errors

P values, the 'gold standard' of statistical validity, are not as reliable as many scientists assume.

By Regina Nuzzo
Nature
Originally published February 12, 2014

For a brief moment in 2010, Matt Motyl was on the brink of scientific glory: he had discovered that extremists quite literally see the world in black and white.

The results were “plain as day”, recalls Motyl, a psychology PhD student at the University of Virginia in Charlottesville. Data from a study of nearly 2,000 people seemed to show that political moderates saw shades of grey more accurately than did either left-wing or right-wing extremists. “The hypothesis was sexy,” he says, “and the data provided clear support.” The P value, a common index for the strength of evidence, was 0.01 — usually interpreted as 'very significant'. Publication in a high-impact journal seemed within Motyl's grasp.

But then reality intervened. Sensitive to controversies over reproducibility, Motyl and his adviser, Brian Nosek, decided to replicate the study. With extra data, the P value came out as 0.59 — not even close to the conventional level of significance, 0.05. The effect had disappeared, and with it, Motyl's dreams of youthful fame.

The entire article is here.

Friday, February 21, 2014

Science Faction: Why Most Scientific Research Results are Wrong

Bloggingheads.tv
John Horgan and George Johnson discuss issues related to science

Why most scientific research results are wrong?

Is competition making fudged data more likely?

Science is not a triumphal march

Can academic publishing be reformed?

Essential and inessential skills for young science writers

The Big Bang and the case against falsifiability


Tuesday, January 21, 2014

Submitting a manuscript for peer review - integrity, integrity, integrity.

Sean P. Murphy, Christopher Bulman, Behnam Shariati and Laura Hausmann-on behalf of the ISN Publications Committee
J Neurochem. 2013 Dec 26. doi: 10.1111/j.1471-4159.2013.12644.x.

Abstract

Publication of a flawed manuscript has significant consequences for the progress of science. When this proves to be intentional, science is brought into disrepute and this puts even more pressure on the shrinking resources that society is prepared to invest in research. All scientific journals, including the Journal of Neurochemistry, have witnessed a marked increase in the number of corrections and retractions of published papers over the last 10 years, and uncovered a depressingly large number of fabrications amongst submitted manuscripts. The increase in number of 'spoiled' manuscripts reflects not only the improved methods that journals employ to detect plagiarism in its many forms, but also suggests a measurable change in the behavior of authors. The increased policing of submissions by reviewers, editors and publishers expends time and money. The sanctions imposed by journal editors on authors found guilty of malpractice are transparent and severe.

Never let the truth stand in the way of a good story 
Mark Twain

While imagination is the source of vibrant fiction, the ‘stories’ we offer in manuscripts submitted for publication have to be faithful. With the beginning of a New Year, it seems appropriate to re-state current Journal of Neurochemistry policies on submissions and, on behalf of the International Society for Neurochemistry, to demand integrity from authors offering manuscripts for scientific review. While the comments here are directed specifically at corresponding authors, the contract entered into with the submission of any manuscript also demands integrity from reviewers, editors and publishers, who
have to be seen to act impartially and promptly in reaching their decisions.

The entire article is here.

Thursday, January 9, 2014

Can we live without free will?

The New Scientist
Opinion
Originally published on August 9, 2012

New research has reignited the debate about whether humans truly have free will. But what difference would it make if we didn't?

DOES it matter if we have free will? Science has been casting doubt on the concept almost from its beginnings. At first, it was the laws of physics that gave pause for thought. The Newtonian "clockwork universe", in which everything unfolds predictably from any given starting position, seemingly affords little scope for human autonomy.

That deterministic vision was overthrown by the introduction of quantum randomness. This hasn't saved free will, though. On the contrary, it has confused the concept of human agency. But few of us see this as reason to abandon our understanding of how free will operates in our everyday lives.

The entire article is here.

Tuesday, December 24, 2013

How journals like Nature, Cell and Science are damaging science

The incentives offered by top journals distort science, just as big bonuses distort banking

By Randy Schekman
The Guardian
Originally posted on December 9, 2013

I am a scientist. Mine is a professional world that achieves great things for humanity. But it is disfigured by inappropriate incentives. The prevailing structures of personal reputation and career advancement mean the biggest rewards often follow the flashiest work, not the best. Those of us who follow these incentives are being entirely rational – I have followed them myself – but we do not always best serve our profession's interests, let alone those of humanity and society.

We all know what distorting incentives have done to finance and banking. The incentives my colleagues face are not huge bonuses, but the professional rewards that accompany publication in prestigious journals – chiefly Nature, Cell and Science.

The entire story is here.

Monday, December 16, 2013

It's time for psychologists to put their house in order

By Keith Laws
The Guardian
Originally published February 27, 2013

Here is an excerpt:

Psychologists find significant statistical support for their hypotheses more frequently than any other science, and this is not a new phenomenon. More than 30 years ago, it was reported that psychology researchers are eight times as likely to submit manuscripts for publication when the results are positive rather than negative.

Unpublished, "failed" replications and negative findings stay in the file-drawer and therefore remain unknown to future investigators, who may independently replicate the null-finding (each also unpublished) - until by chance, a spuriously significant effect turns up.

It is this study that is published. Such findings typically emerge with large effect sizes (usually being tested with small samples), and then shrivel as time passes and replications fail to document the purported phenomenon. If the unreliability of the effect is eventually recognised, it occurs with little fanfare.

The entire story is here.

Sunday, December 1, 2013

The Crisis in Social Psychology: Paul Bloom on Bloggingheads.tv

Paul Bloom interviews Joseph Simmons about the crisis in social psychology.  They discuss the experimental method, the ability to replicate studies, false positives, and studies with "sexy findings".



The entire web site is here.

Monday, November 25, 2013

Bamboozled by Bad Science

The first myth about "evidence-based" therapy

Published on October 31, 2013 by Jonathan Shedler, PhD in Psychologically Minded

Media coverage of psychotherapy often advises people to seek "evidence-based therapy."
Few outside the mental health professions realize the term “evidence-based therapy” is a form of branding. It refers to therapies conducted by following instruction manuals, originally developed to create standardized treatments for research trials. These "manualized" therapies are typically brief, highly structured, and almost exclusively identified with cognitive behavioral therapy or CBT.

Academic researchers routinely extoll the “evidence-based” therapies studied in research laboratories and denigrate psychotherapy as it is actually practiced by most clinicians in the real world. Their comments range from the hysteric (“The disconnect between what clinicians do and what science has discovered is an unconscionable embarrassment.”–Professor Walter Mischel, quoted in Newsweek) to the seemingly cautious and sober (“Evidence-based therapies work a little faster, a little better, and for more problematic situations, more powerfully.”–Professor Steven Hollon, quoted in the Los Angeles Times).

The entire blog post is here.

Thursday, November 14, 2013

Robert Wright Interviews Joshua Greene on his New Book

The Robert Wright Show
Originally published October 13, 2013
Interview with Joshua Green
They discuss his new book: Moral Tribes: Emotion, Reason, and the Gap Between Us and Them


The website is here.

Sunday, November 10, 2013

Decomposing the Will - Book Review

Andy Clark, Julian Kiverstein, and Tillmann Vierkant (eds.), Decomposing the Will, Oxford University Press, 2013, 356pp., $74.00 (hbk), ISBN 9780199746996.

Reviewed by Marcela Herdova, King's College London

Decomposing the Will is a collection of 17 papers that examine recent developments in cognitive sciences in relation to claims about conscious agency (or lack thereof) and the implications of these findings for the free will debate. The overarching theme of the volume is exploring conscious will as "decomposed" into interrelated functions. The volume has four sections. Part 1 surveys scientific research that has been taken by many to support what the editors refer to as "the zombie challenge". The zombie challenge stems from claims about the limited role of consciousness in ordinary behavior. If conscious control is required for free will, this recent scientific research, which challenges conscious efficacy, also undermines free will. In part 2, authors explore various layers of the sense of agency. Part 3 investigates how to use both phenomenology and science to address the zombie challenge and discusses a variety of possible functions for conscious control. Part 4 offers decomposed accounts of the will.

Due to limitations of space, I will offer extended discussion of only a handful of papers. I provide a brief description for the remaining papers.

The entire book review is here.

Monday, November 4, 2013

World Medical Association Declaration of Helsinki

Ethical Principles for Medical Research Involving Human Subjects
World Medical Association
JAMA. Published online October 19, 2013. doi:10.1001/jama.2013.281053

Preamble

1. The World Medical Association (WMA) has developed the Declaration of Helsinki as a statement of ethical principles for medical research involving human subjects, including research on identifiable human material and data.

The Declaration is intended to be read as a whole and each of its constituent paragraphs should be applied with consideration of all other relevant paragraphs.

2. Consistent with the mandate of the WMA, the Declaration is addressed primarily to physicians. The WMA encourages others who are involved in medical research involving human subjects to adopt these principles.

The entire document is here.

Sunday, November 3, 2013

Epigenetics: How to alter your genes

We’ve long been told our genes are our destiny. But it’s now thought they can be changed by habit, lifestyle, even finances. What does this mean for our children?

By Chris Bell
The Telegraph
Originally published on October 16, 2013

Here is an excerpt:

And yet a quiet scientific revolution is changing that thinking. For it seems you might also be what your mother ate. How much your father drank. And what your grandma smoked. Likewise your own children, too, may be shaped by whether you spend your evenings jogging, worrying about work, or sat on the sofa eating Wotsits. And that nurture, rather than our intractable nature, may determine who we are far more than was ever previously thought.

Epigenetics is a relatively new scientific field; research only began in earnest in the mid Nineties, and has only found traction in the wider scientific community in the last decade or so. And the sources of its data are eclectic, to say the least – stretching from famines in northern Sweden to the 9/11 attacks to the medical notes of Audrey Hepburn.

The entire story is here.