Welcome to the Nexus of Ethics, Psychology, Morality, Philosophy and Health Care

Welcome to the nexus of ethics, psychology, morality, technology, health care, and philosophy
Showing posts with label Basic Research. Show all posts
Showing posts with label Basic Research. Show all posts

Thursday, February 22, 2018

NIH adopts new rules on human research, worrying behavioral scientists

William Wan
The Washington Post
Originally posted January 24, 2018

Last year, the National Institutes of Health announced plans to tighten its rules for all research involving humans — including new requirements for scientists studying human behavior — and touched off a panic.

Some of the country’s biggest scientific associations, including the American Psychological Association and Federation of Associations in Behavioral and Brain Sciences, penned impassioned letters over the summer warning that the new policies could slow scientific progress, increase red tape and present obstacles for researchers working in smaller labs with less financial and administrative resources to deal with the added requirements. More than 3,500 scientists signed an open letter to NIH director Francis Collins.

The new rules are scheduled to take effect Thursday. They will have a big impact on how research is conducted, especially in fields like psychology and neuroscience. NIH distributes more than $32 billion each year, making it the largest public funder of biomedical and health research in the world, and the rules apply to any NIH-supported work that studies human subjects and is evaluating the effects of interventions on health or behavior.

The article is here.

Thursday, December 17, 2015

Harvard Medical School Eases on Contentious Ethics Rule

By Melissa Bailey
Stat News
Originally published on November 30, 2015

Here is an excerpt:

“Nobody wants conflict-of-interest rules to stop basic research if the conflict can be managed,” he said.

The school also lifted the $30,000 cap for publicly traded companies, saying instead that faculty who accept sponsored research from a company cannot own equity amounting to over 1 percent of that company’s value.

Dr. Donald Ingber, who directs Harvard’s Wyss Institute for Biologically Inspired Engineering, called the changes “subtle” but “a move in the right direction.”

“Whenever there’s greater flexibility, it increases the likelihood of greater translation” of discoveries into clinical applications, he said, which is the goal of the Wyss.

“The higher the wall, the more difficult it is to jump over that wall,” he said. “This’ll make it a little bit easier to collaborate.”

The entire article is here.

Friday, June 26, 2015

Rein It In, Dr Oz

By Art Caplan
MedScape
Originally published April 30, 2015

Dr Mehmet Oz is in trouble again. He was accused by 10 physicians in a letter of promoting quackery. They demanded that Columbia University Medical Center fire Dr Oz. Now, I can say with some authority that as "America's Doctor"—the person who, for many Americans, is the voice of medicine—he is not going to be fired. His show is not going to end. That isn't going to happen.

Dr Oz has evoked this response from these 10 physicians because he continues to push the border of legitimacy on his shows with respect to touting things for which there isn't much evidence. And that is a problem. Many doctors tell me that when Dr Oz endorses something—green coffee beans, some neti pot to cure the common cold—whatever it is, they are going to be asked about it, and their patients run out and buy it. He has enormous power when it comes to the platform he has built. And let's face it: He is an effective communicator. His show is fun to watch. I understand why the American people are paying attention to Dr Oz.

The entire article is here.

Saturday, April 11, 2015

Amid a Sea of False Findings, the NIH Tries Reform; Science needs to get its house in order, says Francis Collins, director of the NIH

By Paul Voosen
Chronicle of Higher Education
Originally published March 16, 2015

How do you change an entire scientific culture?

It may sound grandiose, but that is the loaded question now facing the National Institutes of Health, the federal agency that oversees and finances U.S. biomedical research.

While the public remains relatively unaware of the problem, it is now a truism in the scientific establishment that many preclinical biomedical studies, when subjected to additional scrutiny, turn out to be false.

Many researchers believe that if scientists set out to reproduce preclinical work published over the past decade, a majority would fail.

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The NIH, if it was at first reluctant to consider the problem, is now taking it seriously. Just over a year ago, the agency's director, Francis S. Collins, and his chief deputy, Lawrence A. Tabak, announced actions the agency would take to improve the research it finances.

Science needs to get its house in order, Dr. Collins said in a recent interview with The Chronicle.

The entire article is here.

Friday, September 26, 2014

Females ignored in basic medical research

By Erin White
Science Daily
Published August 28, 2014

A new study from Northwestern Medicine® has found that surgical researchers rarely use female animals or female cells in their published studies -- despite a huge body of evidence showing that sex differences can play a crucial role in medical research.

Editors of the five major surgical journals reviewed in this study have responded to this finding and will now require authors to state the sex of animals and cells used in their studies. If they use only one sex in their studies, they will be asked to justify why.

The entire article is here.

Wednesday, July 30, 2014

Corruption of Peer Review Is Harming Scientific Credibility

By Hank Campbell
The Wall Street Journal
Originally published July 13, 2013

Academic publishing was rocked by the news on July 8 that a company called Sage Publications is retracting 60 papers from its Journal of Vibration and Control, about the science of acoustics. The company said a researcher in Taiwan and others had exploited peer review so that certain papers were sure to get a positive review for placement in the journal. In one case, a paper's author gave glowing reviews to his own work using phony names.

Acoustics is an important field. But in biomedicine faulty research and a dubious peer-review process can have life-or-death consequences. In June, Dr. Francis Collins, director of the National Institutes of Health and responsible for $30 billion in annual government-funded research, held a meeting to discuss ways to ensure that more published scientific studies and results are accurate.

The entire article is here.

Tuesday, July 29, 2014

Can a Jury Believe What It Sees?

Videotaped Confessions Can Be Misleading

By Jennifer L. Mnookin
The New York Times
Originally published July 13, 2014

Here is an excerpt:

The short answer is that, according to recent research, interrogation recording may in fact be too vivid and persuasive. Even seemingly neutral recordings still require interpretation. As advertisers and Hollywood directors know well, camera angles, close-ups, lenses and dozens of other techniques shape our perception of what we see without our being aware of it.

In a series of experiments led by the psychologist G. Daniel Lassiter of Ohio University, mock juries were shown exactly the same interrogation, but some saw only the defendant, while others had a wider-angle view that included the interrogator. When the interrogator isn’t shown on camera, jurors are significantly less likely to find an interrogation coercive, and more likely to believe in the truth and accuracy of the confession that they hear — even when the interrogator explicitly threatens the defendant.

The entire article is here.

Thursday, July 17, 2014

Furor Erupts Over Facebook's Experiment on Users

By Reed Albergotti
The Wall Street Journal
Originally published June 30, 2014

Here is an excerpt:

The research, published in the March issue of the Proceedings of the National Academy of Sciences, sparked a different emotion - outrage - among some people who say Facebook toyed with its users emotions and uses members as guinea pigs.

"What many of us feared is already a reality: Facebook is using us as lab rats, and not just to figure out which ads we'll respond to but actually change our emotion," wrote Animalnewyork.com, a blog post that drew attention to the study Friday morning.

Facebook has long run social experiments.  Its Data Science Team is tasked with turning the reams of information created by the more than 800 million people who log on every day into usable scientific research.

The entire article is here.

Friday, May 30, 2014

N.I.H. Tells Researchers to End Sex Bias in Early Studies

By Roni Caryn Rabin
The New York Times
Originally published May 14, 2014

Amid growing evidence that many drugs are not as effective in women as in men, the National Institutes of Health on Wednesday warned scientists that they must take steps to alter longstanding basic research methods.

The N.I.H. has already taken researchers to task for their failure to include adequate numbers of women in clinical trials. The new announcement is an acknowledgment that this gender disparity begins much earlier in the research process.

Even in the most preliminary stages of investigation, many scientists for decades have tested their theories only in male lab rats or only in male tissues and cells. Now the N.I.H. wants scientists that it funds to include female lab animals and female cell lines.

The entire article is here.

Thursday, May 15, 2014

The Reformation: Can Social Scientists Save Themselves?

By Jerry Adler
Pacific Standard: The Science of Society
Originally posted April 28, 2014

Here is two excerpts to a long, yet exceptional, article on research in the social sciences:

OUTRIGHT FAKERY IS CLEARLY more common in psychology and other sciences than we’d like to believe. But it may not be the biggest threat to their credibility. As the journalist Michael Kinsley once said of wrongdoing in Washington, so too in the lab: “The scandal is what’s legal.” The kind of manipulation that went into the “When I’m Sixty-Four” paper, for instance, is “nearly universally common,” Simonsohn says. It is called “p-hacking,” or, more colorfully, “torturing the data until it confesses.”

P is a central concept in statistics: It’s the mathematical factor that mediates between what happens in the laboratory and what happens in the real world. The most common form of statistical analysis proceeds by a kind of backwards logic: Technically, the researcher is trying to disprove the “null hypothesis,” the assumption that the condition under investigation actually makes no difference.

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WHILE IT IS POSSIBLE to detect suspicious patterns in scientific data from a distance, the surest way to find out whether a study’s findings are sound is to do the study all over again. The idea that experiments should be replicable, producing the same results when run under the same conditions, was identified as a defining feature of science by Roger Bacon back in the 13th century. But the replication of previously published results has rarely been a high priority for scientists, who tend to regard it as grunt work. Journal editors yawn at replications. Honors and advancement in science go to those who publish new, startling results, not to those who confirm—or disconfirm—old ones.

The entire article is here.

Thursday, May 8, 2014

We Aren’t the World

By Ethan Watters
Pacific Standard
Originally published February 25, 2013

Here is an excerpt:

The potential implications of the unexpected results were quickly apparent to Henrich. He knew that a vast amount of scholarly literature in the social sciences—particularly in economics and psychology—relied on the ultimatum game and similar experiments. At the heart of most of that research was the implicit assumption that the results revealed evolved psychological traits common to all humans, never mind that the test subjects were nearly always from the industrialized West. Henrich realized that if the Machiguenga results stood up, and if similar differences could be measured across other populations, this assumption of universality would have to be challenged.

Henrich had thought he would be adding a small branch to an established tree of knowledge. It turned out he was sawing at the very trunk. He began to wonder: What other certainties about “human nature” in social science research would need to be reconsidered when tested across diverse populations?

The entire article is here.

Friday, April 25, 2014

Happiness and Its Discontents

By Daniel Haybron
The New York Times
Originally posted April 13, 2014

Here are two excerpts:

Over the past 30 years or so, as the field of happiness studies has emerged from social psychology, economics and other disciplines, many researchers have had the same thought. Indeed this “life satisfaction” view of happiness lies behind most of the happiness studies you’ve read about. Happiness embodies your judgment about your life, and what matters for your happiness is something for you to decide.

This is an appealing view. But I have come to believe that it is probably wrong. Or at least, it can’t do justice to our everyday concerns about happiness.

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I would suggest that when we talk about happiness, we are actually referring, much of the time, to a complex emotional phenomenon. Call it emotional well-being. Happiness as emotional well-being concerns your emotions and moods, more broadly your emotional condition as a whole. To be happy is to inhabit a favorable emotional state.

The entire story is here.

Note: This article has implications for psychological treatment and psychological health.


Saturday, April 12, 2014

In Genes We Trust: How Our Essentialist Biases Distort How We Think About Genes

Posted by Peter B. Reiner
Neuroethics at the Core
Posted March 7, 2014

This video was recorded on October 23-25, 2013 during a Peter Wall Institute for Advanced Studies International Roundtable, "We Are Our Brains", led by Principal Investigator Dr. Peter B. Reiner (Department of Psychiatry, UBC and the National Core for Neuroethics).

To learn more about We Are Our Brains.


Friday, April 11, 2014

How your brain makes moral judgments

By Elizabeth Landau
CNN
Originally posted March 26, 2014

Here is an excerpt:

A moral network?

Scientists have shown that there is a specific network of brain regions involved in mediating moral judgment. An influential study on this topic was published in 2001 and led by Joshua D. Greene, associate professor at Harvard University, author of "Moral Tribes: Emotion, Reason, and the Gap Between Us and Them."

Adrian Raine and Yaling Yang, in a 2006 review article, described this study as a breakthrough. It focused "on the specific difference between making judgments (i.e. 'appropriate' or 'inappropriate') on 'moral personal' dilemmas (e.g. throwing a person out of a sinking life-boat to save others), and 'moral impersonal' dilemmas (e.g. keeping money found in a lost wallet)," they wrote.

The entire article is here.

Tuesday, March 11, 2014

Friend or Foe? Early Social Evaluation of Human Interactions

Buon M, Jacob P, Margules S, Brunet I, Dutat M, et al. (2014) Friend or Foe? Early Social Evaluation of Human Interactions. PLoS ONE 9(2): e88612. doi:10.1371/journal.pone.0088612

Abstract

We report evidence that 29-month-old toddlers and 10-month-old preverbal infants discriminate between two agents: a pro-social agent, who performs a positive (comforting) action on a human patient and a negative (harmful) action on an inanimate object, and an anti-social agent, who does the converse. The evidence shows that they prefer the former to the latter even though the agents perform the same bodily movements. Given that humans can cause physical harm to their conspecifics, we discuss this finding in light of the likely adaptive value of the ability to detect harmful human agents.

The entire article is here.

Sunday, March 2, 2014

Scientific method: Statistical errors

P values, the 'gold standard' of statistical validity, are not as reliable as many scientists assume.

By Regina Nuzzo
Nature
Originally published February 12, 2014

For a brief moment in 2010, Matt Motyl was on the brink of scientific glory: he had discovered that extremists quite literally see the world in black and white.

The results were “plain as day”, recalls Motyl, a psychology PhD student at the University of Virginia in Charlottesville. Data from a study of nearly 2,000 people seemed to show that political moderates saw shades of grey more accurately than did either left-wing or right-wing extremists. “The hypothesis was sexy,” he says, “and the data provided clear support.” The P value, a common index for the strength of evidence, was 0.01 — usually interpreted as 'very significant'. Publication in a high-impact journal seemed within Motyl's grasp.

But then reality intervened. Sensitive to controversies over reproducibility, Motyl and his adviser, Brian Nosek, decided to replicate the study. With extra data, the P value came out as 0.59 — not even close to the conventional level of significance, 0.05. The effect had disappeared, and with it, Motyl's dreams of youthful fame.

The entire article is here.

Tuesday, February 18, 2014

Suicide and the 'Impure' Soul

New research says moral bias against suicide often comes from disgust over a tainted soul.

By Matthew Hutson
The Atlantic
Originally published January 9, 2014

Around the world, about one million people die of suicide each year, according to the World Health Organization. Each death causes immeasurable harm: Friends, family members, and coworkers suffer loss, guilt, and confusion, and the immediate victim loses a future. Many of those friends and family members consider suicide to be morally wrong. But new evidence shows that people who consider suicide wrong might have other reasons than the harm it brings. There is a more abstract—and at the same time more visceral—consideration at play.

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The notion that suicide is wrong because it taints the soul might sound foreign to atheists. But even when only non-religious liberals were considered (those who rated themselves below the midpoint on religious belief and political conservatism), the wrongness of the suicides was still predicted by ratings of purity and not by ratings of harm. According to Rottman, the pattern holds even among people who gave themselves the lowest possible rating on religiosity (1 of 7). Concern about the soul’s purity is not just for church-goers.

The entire article is here.

Tuesday, February 4, 2014

Virtual Reality Moral Dilemmas Show Just How Utilitarian We Really Are

Science Daily
Originally published January 15, 2014

"Moral" psychology has traditionally been studied by subjecting individuals to moral dilemmas, that is, hypothetical choices regarding typically dangerous scenarios, but it has rarely been validated "in the field." This limitation may have led to systematic bias in hypotheses regarding the cognitive bases of moral judgements. A study relying on virtual reality has demonstrated that, in real situations, we might be far more "utilitarian" than believed so far.

The entire article is here.

Thursday, January 30, 2014

In Life and Business, Learning to Be Ethical

By Alina Tugend
The New York Times
Originally published January

Here is an excerpt:

Trying to become more ethical — or teaching people how to — would seem doomed then. But that’s not true. It’s just that how we teach ethics has to catch up with what we know about how the human mind works.

One area clearly in need of attention is business ethics, especially given the transgressions in the financial world in recent years. Some of the nation’s top researchers think so too. Next week, a group of them — most based at American universities — will officially introduce a new website, EthicalSystems.org. The site is the first to pull together extensive research and resources on the subject of business ethics with the aim of making the vast trove available to schools, government regulators and businesses — especially their compliance officers.

“It used to be business ethics grew out of philosophy, with a focus on the right thing to do,” said Jonathan Haidt, a professor of ethical leadership at New York University’s Leonard N. Stern School of Business. “In the last 10 years there’s been an explosion of research in behavioral economics” and the underlying reasons people act the way they do.

The entire article is here.

Saturday, January 25, 2014

The Dark Side of Emotional Intelligence

In some jobs, being in touch with emotions is essential. In others, it seems to be a detriment. And like any skill, being able to read people can be used for good or evil.

Adam Grant
The Atlantic
Originally published January 2, 2014

Here is an excerpt:

Emotional intelligence is important, but the unbridled enthusiasm has obscured a dark side. New evidence shows that when people hone their emotional skills, they become better at manipulating others. When you’re good at controlling your own emotions, you can disguise your true feelings. When you know what others are feeling, you can tug at their heartstrings and motivate them to act against their own best interests.

Social scientists have begun to document this dark side of emotional intelligence. In emerging research led by University of Cambridge professor Jochen Menges, when a leader gave an inspiring speech filled with emotion, the audience was less likely to scrutinize the message and remembered less of the content. Ironically, audience members were so moved by the speech that they claimed to recall more of it.

The authors call this the awestruck effect, but it might just as easily be described as the dumbstruck effect. One observer reflected that Hitler’s persuasive impact came from his ability to strategically express emotions—he would “tear open his heart”—and these emotions affected his followers to the point that they would “stop thinking critically and just emote.”

The entire story is here.