Breakthrough as scientists grow sheep embryos containing human cells

Nicola Davis
The Guardian
Originally published February 17, 2018

Growing human organs inside other animals has taken another step away from science-fiction, with researchers announcing they have grown sheep embryos containing human cells.

Scientists say growing human organs inside animals could not only increase supply, but also offer the possibility of genetically tailoring the organs to be compatible with the immune system of the patient receiving them, by using the patient’s own cells in the procedure, removing the possibility of rejection.

According to NHS Blood and Transplant, almost 460 people died in 2016 waiting for organs, while those who do receive transplants sometimes see organs rejected.

“Even today the best matched organs, except if they come from identical twins, don’t last very long because with time the immune system continuously is attacking them,” said Dr Pablo Ross from the University of California, Davis, who is part of the team working towards growing human organs in other species.

Ross added that if it does become possible to grow human organs inside other species, it might be that organ transplants become a possibility beyond critical conditions.

The information is here.

Is it Ethical for Scientists to Create Nonhuman Primates with Brain Disorders?

Carolyn P. Neuhaus
The Hastings Center
Originally published on September 25, 2017

Here is an excerpt:

Such is the rationale for creating primate models: the brain disorders under investigation cannot be accurately modelled in other nonhuman organisms, because of differences in genetics, brain structure, and behaviors. But research involving humans with brain disorders is also morally fraught. Some people with brain disorders experience impairments to decision-making capacity as a component or symptom of disease, and therefore are unable to provide truly informed consent to research participation. Some of the research is too invasive, and would be grossly unethical to carry out with human subjects. So, nonhuman primates, and macaques in particular, occupy a “sweet spot.” Their genetic code and brain structure are sufficiently similar to humans’ so as to provide a valid and accurate model of human brain disorders. But, they are not conferred protections from research that apply to humans and to some non-human primates, notably chimpanzees and great apes. In the United States, for example, chimpanzees are protected from invasive research, but other primates are not. Some have suggested, including in a recent article in Journal of Medical Ethics, that protections like those afforded to chimpanzees ought to be extended to other primates and other animals, such as dogs, as evidence mounts that they also have complex cognitive, social, and emotional lives. For now, macaques and other primates remain in use.

Prior to the discovery of genome editing tools like ZFNs, TALENs, and most recently, CRISPR, it was extremely challenging, almost to the point of prohibitive, to create non-human primates with precise, heritable genome modifications. But CRISPR (Clustered Randomized Interspersed Palindromic Repeat) presents a technological advance that brings genome engineering of non-human primates well within reach.

The article is here.

Workshop on ethics of monkey research earns cheers and boos

By David Grimm
Science Insider
Originally posted September 8, 2016

Here is an excerpt:

Jeffrey Kahn, a bioethicist at Johns Hopkins University in Baltimore, Maryland, and the chair of the chimpanzee report, added that nonhuman primate research should only be conducted if it has to be conducted. “It’s not ethically acceptable to do research that is not necessary. Being ‘necessary’ is not the same as ‘worth doing.’”

That led to a debate about just what constituted “necessary” and “moral justification.” Even research that doesn’t have an immediate translation to people—like figuring out how the monkey brain works—is necessary, argued Newsome, because it could eventually lead to significant new knowledge that might improve human health. “It will be a tragedy for the world if we don’t leave room for basic science.” Most attendees seemed to agree, with some stating that not doing research on monkeys was ethically indefensible because humans would suffer down the line.

Despite that ethical debate, animal welfare groups said they were upset that science—not welfare—dominated the workshop. Of the 13 speakers, eight make their living working with nonhuman primates. The workshop also only devoted 2 minutes—instead of its scheduled 30 minutes—to public comments. “We are extremely disappointed that no animal protection groups were invited,” wrote Kathleen Conlee, vice president of animal research issues for The Humane Society of the United States in Washington, D.C., in an email to ScienceInsider. “It is clear that NIH has not followed through on what Congress requested, which was to examine ethical policies and processes.”

The article is here.